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DOI: 10.1055/s-0037-1613689
Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006–2014
Transmissão vertical do HIV-1 na área metropolitana de Belo Horizonte, Brasil: 2006–2014Publication History
30 August 2017
08 November 2017
Publication Date:
18 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00030576/201802/lookinside/thumbnails/10-1055-s-0037-1613689_0139-1.jpg)
Abstract
Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014.
Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil.
Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0–3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3–33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7–2.7), but it was not associated with VT.
Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998–2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-to-child transmission (MTCT) of HIV.
Resumo
Objetivo Rever as taxas de transmissão vertical (TV) do HIV-1 na área metropolitana de Belo Horizonte, Brasil, de janeiro de 2006 a dezembro de 2014.
Métodos Estudo descritivo de uma coorte prospectiva de gestantes infectadas pelo HIV-1 e seus filhos, monitorados pelo Grupo de Pesquisa em HIV/Aids Materno-Infantil, da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brasil.
Resultados A taxa geral de TV foi de 1,9% (13/673; intervalo de confiança [IC] 95%: 1,0–3,3). O uso extensivo de terapia antirretroviral combinada (TARVc) (89,7%; 583/650) impactou fortemente a redução de TV durante este período. Carga viral materna superior a 1.000 cópias/mL mostrou associação significante com TV (OR: 6,6; IC 95%:1,3–33,3). A amamentação materna foi descrita em 10 casos nesta coorte (1,5%; IC 95%: 0,7–2,7), mas não foi associada à TV.
Conclusão Os dados atuais da coorte foram coerentes com a baixa taxa de TV descrita em outras populações globais, e foi consideravelmente menor em comparação com os resultados da mesma coorte no período de 1998–2005, quando a taxa de TV foi de 6,2%. Esses dados confirmam a eficiência das Diretrizes Nacionais, e enfatizam a importância de adotar os procedimentos internacionais recomendados para a prevenção da transmissão do HIV da mãe para o filho.
Keywords
HIV infections - infectious disease vertical transmission - highly active antiretroviral therapy - infectious pregnancy complicationsPalavras-Chave
infecções por HIV - transmissão vertical de doença infecciosa - terapia antirretroviral de alta atividade - complicações infecciosas na gravidezContributors
Melo V. H., Maia M. M. M., Correa Júnior M. D., Kakehasi F. M., Ferreira F. G. F., Andrade B. A. M., Scaramussa F. S., Ferreira F. A. M., Messias A. A. and Pinto J. A. declared to have contributed with the conception of the study, collection, and tabulation, critically reviewing intellectual, drafting of the manuscript and final approval of the version to be published.
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