Thromb Haemost 2003; 90(02): 362-363
DOI: 10.1055/s-0037-1613490
Letters to the Editor
Schattauer GmbH

Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia

Cécile V. Denis
,
Virgine Terraube
,
Karine Robert
,
Nathalie Janel
Further Information

Publication History

Received 24 March 2003

Accepted after revision 02 May 2003

Publication Date:
09 December 2017 (online)

 

 
  • References

  • 1 Eberhardt RT, Forgione MA, Cap A. et al. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest 2000; 106: 483-91.
  • 2 Lentz SR, Erger RA, Dayal S. et al Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol Heart Circ Physiol 2000; 279: H970-975.
  • 3 Dayal S, Bottiglieri T, Arning E. et al. Endo-thelial dysfunction and elevation of S-adeno-sylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res 2001; 88: 1203-9.
  • 4 Weiss N, Zhang YY, Heydrick S, Bierl C, Los-calzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc Natl Acad Sci US A 2001; 98: 12503-8.
  • 5 Watanabe M, Osada J, Aratani Y. et al. Micedeficient in cystathionine beta-synthase: ani-mal models for mild and severe homo-cyst(e)inemia. Proc Natl Acad Sci USA 1995; 92: 1585-9.
  • 6 Blann AD, Taberner DA. A reliable marker of endothelial cell dysfunction: does it exist?. Br J Haematol 1995; 90: 244-8.
  • 7 Denis C, Methia N, Frenette PS. et al. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sei U S A 1998; 95: 9524-9.
  • 8 Lentz SR, Sadler JE. Homocysteine inhibitsvon Willebrand factor processing and secre-tion by preventing transport from the endo-plasmic reticulum. Blood 1993; 81: 683-9.
  • 9 Outinen PA, Sood SK, Pfeifer SI. et al. Homo-cysteine-induced endoplasmic reticulum stressand growth arrest leads to specific changes in gene expression in human vascular endothelialcells. Blood 1999; 94: 959-67.