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Thromb Haemost 2001; 85(01): 114-118
DOI: 10.1055/s-0037-1612913
Review Article
Schattauer GmbH

Antithrombotic Efficacy in a Rat Model of the Low Molecular Weight Heparin, Reviparin Sodium, Administered by the Oral Route

Linda M. Hiebert
1   Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
,
Sandra M. Wice
1   Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
,
Tilly Ping
1   Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
,
Dieter Herr
2   Knoll AG, Ludwigshafen, Germany
,
Volker Laux
2   Knoll AG, Ludwigshafen, Germany
› Institutsangaben
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Publikationsverlauf

Received 10. April 2000

Accepted after revision 27. Juli 2000

Publikationsdatum:
08. Dezember 2017 (online)

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Summary

Previous studies in rats show that unfractionated heparin and the low molecular weight heparin logiparin have a dose-dependent antithrombotic effect and are found in endothelium and plasma when administered orally. Objectives of the present study were to determine if similar evidence of absorption could be observed with oral reviparin sodium. Thrombosis incidence was determined 4 h after application of 10% formalin in methanol to the exposed jugular vein. A dose-dependent antithrombotic effect was observed when 0.01 to 7.5 mg/kg (20 rats/group) was administered by stomach tube immediately following thrombus initiation. Thrombotic incidence was also significantly reduced when 0.025 mg/kg was given 4 and 2 h prior to, immediately after, and 2 and 3 h following thrombus initiation. Reviparin was recovered from endothelium and plasma in trace amounts at all doses. At 0.025 mg/kg, peak aortic endothelial reviparin concentrations were found at 1 and 2 h and peak plasma anti-Xa activity was detected at 2 h. Trace amounts of plasma TFPI were found only at 8 h after administration. Dose-dependent antithrombotic activity and recovery from endothelium and plasma support the hypothesis that orally administered reviparin sodium is absorbed.

Keywords

Reviparin sodium - thrombosis - oral - rats
 

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