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Synthesis 2019; 51(09): 2023-2029
DOI: 10.1055/s-0037-1612101
DOI: 10.1055/s-0037-1612101
paper
One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of α-Nitro Epoxides
This project was supported by the Natural Science Foundation of Zhejiang Province [LY16H300001 (G. Zhang), LY18H300001 (W. Chen)], the National Natural Science Foundation of China (81473074 and 81673291) and the Osteoporosis & Breast Cancer Research Center, USA (Y. Yu).Further Information
Publication History
Received: 28 October 2018
Accepted after revision: 28 December 2018
Publication Date:
18 February 2019 (online)


Abstract
Polysubstituted 2-aminothiazoles have been synthesized via a one-pot three-component reaction of α-nitro epoxides, potassium thiocyanate, and primary amines without the need for any additives. This reaction proceeds smoothly in a highly efficient and eco-friendly manner with good to excellent yields. A possible mechanism is also proposed.
Key words
2-aminothiazoles - nitro epoxides - potassium thiocyanate - primary amines - one-pot synthesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1612101.
- Supporting Information