Synlett 2019; 30(13): 1573-1579
DOI: 10.1055/s-0037-1611856
letter
© Georg Thieme Verlag Stuttgart · New York

Hypervalent Iodine Mediated Efficient Solvent-Free Regioselective Halogenation and Thiocyanation of Fused N-Heterocycles

Divakar Reddy Indukuri
a   Flouro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India
b   Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India   Email: manjula@iict.res.in
,
Gal Reddy Potuganti
a   Flouro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India
b   Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India   Email: manjula@iict.res.in
,
Manjula Alla*
a   Flouro & Agrochemicals Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India
b   Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India   Email: manjula@iict.res.in
› Author Affiliations
I.D.R. thanks DST and P.G.R. thanks CSIR, for a fellowship.
Further Information

Publication History

Received: 18 March 2019

Accepted after revision: 16 May 2019

Publication Date:
12 June 2019 (online)


Abstract

A facile, rapid, metal-free regioselective halogenation and thiocyanation of imidazo[1,2-a]pyridine/pyrimidine heterocycles has been achieved under solvent-free reaction conditions. Halogenations and thiocyanation of the heterocycles could be accomplished by simple grinding of reactants and hypervalent iodine reagents with the corresponding alkali metal or ammonium salts. The method has been extrapolated to a cleaner synthesis of brominated imidazo[1,2-a]pyridine/pyrimidine derivatives, starting from the corresponding heterocyclic amines and substituted α-bromoketones, utilising HBr generated in situ as the source of bromine.

Supporting Information

 
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  • 18 Analytical data and copies of spectra of all compounds are given in the Supporting Information. Analytical data of a selection of new compounds are given below. 3-Bromo-2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine (3c) Yield: 253 mg (80%); yellow solid; mp 92–94 °C; 1H NMR (500 MHz, CDCl3): δ = 8.08–8.04 (m, 1 H), 8.02 (d, J = 7.0 Hz, 1 H), 7.38 (s, 1 H), 7.03–6.99 (m, 2 H), 6.74 (dd, J = 7.0, 1.5 Hz, 1 H), 3.86 (s, 3 H), 2.42 (s, 3 H). 13C NMR (100 MHz, CDCl3): δ = 159.57, 145.52, 141.94, 136.15, 129.02, 125.35, 122.96, 115.65, 115.50, 113.81, 89.96, 77.00, 55.24, 21.28. HRMS-ESI: m/z [M + H]+ calcd. for C15H14BrN2O: 317.0284; found: 317.0290. 3-Bromo-7-methyl-2-(p-tolyl)imidazo[1,2-a]pyridine (3l) Yield: 234 mg (78%); white solid; mp 176–178 °C; 1H NMR (400 MHz, CDCl3): δ = 8.00 (dd, J = 7.5, 5.8 Hz, 3 H), 7.37 (s, 1 H), 7.29–7.25 (m, 2 H), 6.70 (dd, J = 7.0, 1.5 Hz, 1 H), 2.40 (s, 6 H). 13C NMR (125 MHz, CDCl3): δ = 145.64, 142.27, 137.95, 136.02, 130.04, 129.08, 127.60, 122.98, 115.81, 115.49, 90.41, 77.00, 21.28. HRMS-ESI: m/z [M + H]+ calcd. for C15H14BrN2: 301.0348; found: 301.0340. 3-Bromo-2-(thiophen-2-yl)imidazo[1,2-a]pyrimidine (3m) Yield: 232 mg (84%); white solid; mp 150–152 °C; 1H NMR (400 MHz, CDCl3): δ = 8.56 (dd, J = 4.0, 1.8 Hz, 1 H), 8.40 (dd, J = 6.8, 1.8 Hz, 1 H), 7.95 (d, J = 3.6 Hz, 1 H), 7.45 (d, J = 5.0 Hz, 1 H), 7.20–7.14 (m, 1 H), 6.99 (dd, J = 6.8, 4.1 Hz, 1 H). 13C NMR (125 MHz, CDCl3): δ = 150.23, 147.99, 140.28, 135.12, 131.15, 127.74, 127.28, 126.71, 109.36, 89.31, 77.00. HRMS-ESI: m/z [M + H]+ calcd. for C10H7BrN3S: 279.9543; found: 279.9544. 3-Bromo-2-(3-nitrophenyl)imidazo[1,2-a]pyrimidine (3n) Yield: 214 mg (68%); white solid; mp 224–226 °C; 1H NMR (300 MHz, CDCl3+DMSO): δ = 9.12 (s, 1 H), 8.67 (dd, J = 4.1, 1.9 Hz, 1 H), 8.65–8.57 (m, 2 H), 8.27 (dd, J = 8.2, 1.2 Hz, 1 H), 7.72 (t, J = 8.0 Hz, 1 H), 7.15 (dd, J = 6.8, 4.1 Hz, 1 H). 13C NMR (75 MHz, CDCl3+DMSO): δ = 150.36, 147.28, 147.06, 139.91, 133.11, 132.40, 131.32, 128.71, 122.07, 121.29, 109.15, 90.40, 77.00. HRMS-ESI: m/z [M + H]+ calcd. for C12H8BrN4O2: 317.9749; found: 317.9752. 3-Bromo-7-methyl-2-(p-tolyl)imidazo[1,2-a]pyrimidine (3p) Yield: 241 mg (80%); brown solid; mp 180–182 °C; 1H NMR (400 MHz, CDCl3): δ = 8.28 (d, J = 7.0 Hz, 1 H), 8.14–8.10 (m, 2 H), 7.29 (d, J = 8.0 Hz, 2 H), 6.85–6.82 (m, 1 H), 2.66 (s, 3 H), 2.41 (s, 3 H). 13C NMR (125 MHz, CDCl3): δ = 160.32, 148.05, 143.39, 138.52, 130.58, 129.60, 129.13, 127.73, 110.08, 88.91, 77.00, 24.84, 21.35. HRMS-ESI: m/z [M + H]+ calcd. for C13H11BrN3: 288.0140; found: 288.0136. HRMS-ESI: m/z [M + H]+, calcd. for C14H13BrN3: 302.0293; found: 302.0287. 3-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyrimidine (3q) Yield: 249 mg (82%); white solid; mp 154–156 °C; 1H NMR (400 MHz, CDCl3): δ = 8.57 (dd, J = 4.1, 2.0 Hz, 1 H), 8.45 (dd, J = 6.8, 2.0 Hz, 1 H), 8.22–8.16 (m, 2 H), 7.05–6.96 (m, 3 H), 3.88 (s, 3 H). 13C NMR (100 MHz, CDCl3): δ = 160.16, 149.79, 148.14, 144.22, 131.18, 129.44, 124.79, 113.95, 109.14, 89.38, 77.00, 55.33. HRMS-ESI: m/z [M + H]+ calcd. for C13H10BrN3O: 304.0086; found: 304.0085. 3-Bromo-7-methoxy-2-(4-methoxyphenyl)benzo[d]imidazo [2,1-b]thiazole (12b) Yield: 251 mg (65%); white solid; mp 206–208 °C; 1H NMR (300 MHz, CDCl3): δ = 8.30 (d, J = 9.1 Hz, 1 H), 7.94 (d, J = 8.8 Hz, 2 H), 7.20 (d, J = 2.4 Hz, 1 H), 7.05–6.92 (m, 3 H), 3.87 (d, J = 4.5 Hz, 6 H). 13C NMR (100 MHz, CDCl3): δ = 159.34, 157.31, 147.08, 143.31, 131.54, 128.46, 127.18, 125.18, 114.26, 113.87, 113.06, 108.54, 90.89, 77.00, 55.88, 55.31. HRMS-ESI: m/z [M + H]+ calcd. for C17H14BrN2O2S: 388.9958; found: 388.9959. 3-Bromo-7-methoxy-2-(p-tolyl)benzo[d]imidazo[2,1-b]thiazole (12c) Yield: 260 mg (70%); pale-pink solid; mp 204–206 °C; 1H NMR (400 MHz, CDCl3): δ = 8.31 (d, J = 9.1 Hz, 1 H), 7.90 (d, J = 8.2 Hz, 2 H), 7.26 (t, J = 4.0 Hz, 2 H), 7.20 (d, J = 2.4 Hz, 1 H), 7.01 (dd, J = 9.0, 2.4 Hz, 1 H), 3.88 (s, 3 H), 2.40 (s, 3 H). 13C NMR (125 MHz, CDCl3): δ = 157.27, 147.20, 143.74, 137.63, 131.56, 129.96, 129.11, 127.22, 126.99, 114.26, 112.96, 108.54, 91.33, 77.00, 55.86, 21.31. HRMS-ESI: m/z [M + H]+ calcd. for C17H14BrN2OS: 372.9967; found: 372.9954. 3-Chloro-2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine (4c) Yield: 155 mg (57%); brown solid; mp 122–124 °C; 1H NMR (400 MHz, CDCl3): δ = 8.09–8.04 (m, 2 H), 7.97 (d, J = 7.0 Hz, 1 H), 7.39 (s, 1 H), 7.03–6.98 (m, 2 H), 6.75 (dd, J = 7.0, 1.5 Hz, 1 H), 3.87 (s, 3 H), 2.43 (d, J = 0.6 Hz, 3 H). 13C NMR (125 MHz, CDCl3): δ = 159.60, 143.98, 139.23, 135.94, 128.75, 125.19, 121.82, 115.80, 115.45, 113.99, 104.16, 55.34, 21.41. HRMS-ESI: m/z [M + H]+ calcd. for C15H14OClN2: 273.0792; found: 273.0789. 3-Iodo-2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine (5c) Eluent: hexane/ethyl acetate, 90:10. Yield: 254 mg (70%); white solid; mp 118–120 °C; 1H NMR (400 MHz, CDCl3): δ = 8.06 (d, J = 7.0 Hz, 1 H), 8.00 (d, J = 8.7 Hz, 2 H), 7.35 (s, 1 H), 7.01 (d, J = 8.7 Hz, 2 H), 6.73 (d, J = 6.9 Hz, 1 H), 3.86 (s, 3 H), 2.43 (s, 3 H). 13C NMR (125 MHz, CDCl3): δ = 159.56, 148.23, 147.52, 136.37, 129.59, 126.16, 125.43, 115.71, 115.45, 113.66, 77.00, 57.33, 55.22, 21.19. HRMS-ESI: m/z [M + H]+ calcd. for C15H14IN2O: 365.0146; found: 365.0151. 3-Thiocyanato-2-(p-tolyl)imidazo[1,2-a]pyrimidine (6g) Yield: 223 mg (84%); white solid; mp 208–210 °C; 1H NMR (300 MHz, CDCl3+DMSO): δ = 8.81 (ddd, J = 6.1, 5.5, 1.9 Hz, 2 H), 8.07 (d, J = 8.2 Hz, 2 H), 7.37 (d, J = 8.0 Hz, 2 H), 7.27 (dd, J = 6.7, 4.3 Hz, 1 H), 2.46 (s, 3 H). 13C NMR (75 MHz, CDCl3+DMSO): δ = 151.94, 138.92, 131.87, 128.45, 127.67, 126.76, 109.65, 77.00, 20.38. HRMS-ESI: m/z [M + H]+ calcd. for C14H11IN4S: 267.0695; found: 267.0699.