Synlett 2019; 30(12): 1469-1473
DOI: 10.1055/s-0037-1611847
letter
© Georg Thieme Verlag Stuttgart · New York

Copper Acetate Aerobic Oxidative Synthesis of Pyrido[1,2-a]benzimidazoles from Aminopyridines and Phenylboronic Acids

Hao Yan*
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
b  State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. of China
,
Hui Guo
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
,
Xiaoqiang Zhou
b  State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. of China
c  College of Chemistry and Materials, Weinan Normal University, Chaoyang Road, Weinan 714099, P. R. of China
,
Zhenyu Zuo
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
,
Jingli Liu
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
,
Guanghui Zhang
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
,
Shuan Zhang
a  College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, P. R. of China   Email: yanhao@sntcm.edu.cn
› Author Affiliations
We acknowledge financial support from the Research Funds for the Shaanxi University of Chinese Medicine (2016PY19), Youth Talent Support Project of Shaanxi Association for Science and Technology (20170406). University Students’ Innovative Undertaking of Shaanxi Province (201823033), University Students’ Innovative Undertaking of Shaanxi University of Chinese Medicine (201807028), the Chinese Medicine Project of Shaanxi Province (ZYMS005) and the National Natural Science Foundation of China (81001669).
Further Information

Publication History

Received: 06 April 2019

Accepted after revision: 13 May 2019

Publication Date:
06 June 2019 (eFirst)

Abstract

Pyrido[1,2-a]benzimidazoles, which show interesting and potentially useful biological activities, have drawn extensive attention from chemists. A straightforward copper acetate-oxidative one-pot synthesis of these compounds from 2-aminopyridines and phenylboronic acids through C–N bond formation and C–H bond activation was developed as a simple and convenient method.

Supporting Information

 
  • References and Notes

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