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Synlett 2019; 30(05): 525-531
DOI: 10.1055/s-0037-1611693
DOI: 10.1055/s-0037-1611693
synpacts
Self-Immolative Prodrugs: Effective Tools for the Controlled Release of Sulfur Signaling Species
This work was supported by the National Science Foundation (DMR-1454754) and the National Institutes of Health (R01GM123508). We also thank 3M for support of this work through a Non-Tenured Faculty Award to J.B.M.Further Information
Publication History
Received: 08 November 2018
Accepted after revision: 27 November 2018
Publication Date:
09 January 2019 (online)
◊ These authors contributed equally to this work
Abstract
H2S, persulfides (R–SSH), and related sulfur species have recently received attention due to the pronounced physiological effects they elicit. Delivering sulfur signaling molecules in a controlled manner presents many challenges, as many available donors have short half-lives, lack water solubility, and exhibit poor trigger specificity. Self-immolative prodrugs provide a unique ability to impart stability to H2S precursors and persulfides while allowing for trigger specificity by tuning the functional group installed on the self-immolative linker. This strategy has proven successful in delivering sulfur signaling species under specific conditions and may lead to the further elucidation of persulfide interactions within biological systems, affording effective therapeutics.
1 Introduction
2 Currently Available Persulfide Donors
3 BDP-NAC: An ROS-Responsive Persulfide Prodrug
4 Conclusion
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