Synlett 2019; 30(12): 1479-1483
DOI: 10.1055/s-0037-1611560
letter
© Georg Thieme Verlag Stuttgart · New York

The Allylic Acetoxylation of 1,1-Disubstituted Alkenes Catalyzed by a Palladium(II)/Monothiadiazole Ligand System

Xiaohan Li
a  Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Bin Sun
a  Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Jin Yang
b  College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: jincan@zjut.edu.cn
,
Xun Zhang
b  College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: jincan@zjut.edu.cn
,
Jiayang Wang
a  Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
,
Xiaohui Zhuang
b  College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: jincan@zjut.edu.cn
,
Can Jin*
b  College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: jincan@zjut.edu.cn
,
b  College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: jincan@zjut.edu.cn
› Author Affiliations
This work was supported by the National Natural Science Foundation of China (21676252).
Further Information

Publication History

Received: 08 March 2019

Accepted after revision: 04 May 2019

Publication Date:
05 June 2019 (eFirst)

Abstract

A palladium(II)/monothiadiazole ligand catalytic system and its application in catalyzing the acetoxylation of 1,1-disubstituted alkenes have been developed. With this newly designed monothiadiazole thioether ligand, the reaction showed a broad scope with respect to 1,1-disubstituted olefins, giving the corresponding products in yields of 30–86%.

Supporting Information

 
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