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Synthesis 2019; 51(17): 3336-3344
DOI: 10.1055/s-0037-1611536
DOI: 10.1055/s-0037-1611536
paper
Microwave-Assisted CuCl-Catalyzed Three-Component Reactions of Alkynes, Aldehydes, and Amino Alcohols
This work was supported by the National Natural Science Foundation of China (Grant Nos. 21702014, 21572017 and 21772010), the National Basic Research Program of China (Grant No. 2013CB328905) and the Fundamental Research Funds for the Central Universities (XK1802-6).Further Information
Publication History
Received: 11 February 2019
Accepted after revision: 12 April 2019
Publication Date:
08 May 2019 (online)
Abstract
A microwave (MW)-assisted three-component coupling of amino alcohols, aldehydes, and alkynes is developed under catalysis by CuCl. Compared with thermal conditions, MW irradiation greatly increases the reaction efficiency. The reactions of various primary N-alkyl/arylamino alcohols, aliphatic/aromatic aldehydes, and alkynes are systematically investigated, affording the desired products in moderate to good yields. Notably, acetylene is also an effective reactant under the current MW-assisted conditions.
Key words
microwave-assisted - three-component reactions - propargylamino alcohols - Cu catalysis - A3-couplingSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611536.
- Supporting Information
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