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Synlett 2019; 30(01): 104-108
DOI: 10.1055/s-0037-1611342
DOI: 10.1055/s-0037-1611342
letter
Synthesis of Naphthoic Acids as Potential Anticancer Agents
Weitere Informationen
Publikationsverlauf
Received: 12. September 2018
Accepted after revision: 02. November 2018
Publikationsdatum:
03. Dezember 2018 (online)


Abstract
As part of ongoing research to investigate structural requirements for lactate dehydrogenase inhibition by highly substituted naphthoic acids, nine new aryl-substituted dihydroxynaphthoic acids were synthesized from three known precursors. Described here are efficient preparations of the 1-naphthoic acid target compounds by using Suzuki coupling reactions, formylations, oxidations, and demethylations. Lactate dehydrogenase inhibition studies conducted with five of the compounds revealed values of the inhibitory constant K i in the low micromolar range.
Key words
naphthoic acids - Suzuki coupling - naphthaldehydes - formylation - oxidation - medicinal chemistrySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611342.
- Supporting Information