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Synthesis 2019; 51(10): 2128-2135
DOI: 10.1055/s-0037-1610864
DOI: 10.1055/s-0037-1610864
paper
Synthesis of Chiral Triazole-Based Halogen Bond Donors
The authors thank the Estonian Ministry of Education and Research (Grant Nos. IUT 19-32, IUT 19-9, and PUT1468), the Centre of Excellence in Molecular Cell Engineering, and the Archimedes Foundation (2014-2020.4.01.15-0013) for financial support.Weitere Informationen
Publikationsverlauf
Received: 28. Dezember 2018
Accepted after revision: 02. Februar 2019
Publikationsdatum:
12. März 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201910/lookinside/thumbnails/ss-2018-t0869-op_10-1055_s-0037-1610864-1.jpg)
Abstract
The number of applications that use halogen bonding in the fields of self-assembly, supramolecular aggregation, and catalysis is growing. However, the accessibility of chiral halotriazoles shows that there is still a lot more to explore. The simple click-chemistry is applied for the straightforward synthesis of enantiomerically pure mono- and bidentate as well as multifunctional iodotriazole-based XB donors. The methodology is characterized by a wide variability due to easy access of chiral azides.
Key words
click chemistry - nitrogen heterocycles - halogen bonds - hydrogen bonds - chiral compoundsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610864.
- Supporting Information
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