Gram-Scale Synthesis of β-Sulfonyl Styrenes

Abstract

A simple and gram-scale synthesis of β-sulfonyl styrenes has been developed starting from one-pot PPA (polyphosphoric acid)-catalyzed 1,1-diacetoxylation of arylacetaldehydes (ArCH₂CHO) with acetic anhydride (Ac₂O) followed by deacetoxylative sulfonylation of the resulting 1,1-diacetate intermediate with sodium sulfinates (RSO₂Na) in good yields under solvent-free conditions.

Key words

β-sufonyl styrenes - sodium sulfinates - arylacetaldehydes - gram-scale synthesis

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