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Synthesis 2022; 54(05): 1339-1346
DOI: 10.1055/s-0037-1610787
DOI: 10.1055/s-0037-1610787
paper
Recyclable Pd2dba3/XPhos/PEG-2000 System for Efficient Borylation of Aryl Chlorides: Practical Access to Aryl Boronates
We thank the National Natural Science Foundation of China (No. 21462021), the Natural Science Foundation of Jiangxi Province (No. 20161BAB203086) and Key Laboratory of Functional Small Organic Molecules, Ministry of Education (No. KLFS-KF-201704) for financial support.
Abstract
Pd2dba3/XPhos in poly(ethylene glycol) (PEG-2000) is shown to be a highly stable and efficient catalyst for the borylation of aryl chlorides with bis(pinacolato)diboron. The borylation reaction proceeds smoothly at 110 °C, delivering a wide variety of aryl boronates in good to excellent yields with high functional group tolerance. The crude products were easily isolated via simple extraction of the reaction mixture with cyclohexane. Moreover, both expensive Pd2dba3 and XPhos in PEG-2000 system could be readily recycled and reused more than six times without loss of catalytic efficiency.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610787.
- Supporting Information
Publication History
Received: 12 September 2021
Accepted after revision: 14 October 2021
Article published online:
22 November 2021
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