Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides

Abstract

Herein a bimetallic radical redox-relay strategy is employed to generate alkyl radicals under mild conditions with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to enact base-free isomerizations of N-Bz aziridines to N-Bz allylic amides. This reaction provides an alternative strategy for the synthesis of allylic amides from alkenes via a three-step sequence to accomplish a formal transpositional allylic amination.

Key words

radical redox relay - titanium catalysis - cobalt catalysis - bimetallic - aziridines - allylic amines - allylic amides

Publication History

Received: 11 May 2021

Accepted after revision: 24 June 2021

Article published online:
29 July 2021

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