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Synthesis 2019; 51(04): 829-841
DOI: 10.1055/s-0037-1610349
DOI: 10.1055/s-0037-1610349
short review
Recent Advances in the Synthesis of Unsymmetrical Bisindolylmethane Derivatives
Financial support from the University of Camerino is gratefully acknowledged.Further Information
Publication History
Received: 20 September 2018
Accepted after revision: 05 November 2018
Publication Date:
13 December 2018 (online)
Abstract
This review article summarizes the fundamental synthetic procedures aimed at the preparation of unsymmetrical bisindolylmethanes that have appeared in the literature since 2010. To this goal, reactive electrophilic indole-containing intermediates are mostly generated from indolylmethanols, indolylmethanamines, and indolylmethanthio derivatives and then made to react with simple or functionalized indoles. The asymmetric synthesis of bisindolylmethanes can be also achieved under chiral-catalyzed conditions.
1 Introduction
2 Direct Three-Component Coupling
3 Reaction of Indolylmethanols
4 Reaction of Indolylmethanamine Derivatives
5 Reaction of 3-Vinylindoles
6 Reaction of indolylmethanthio Derivatives
7 Bisindolylmethanes by Ring Closure of Alkyne Derivatives
8 Miscellaneous Methods
9 Conclusion
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For general reviews on the utilization of this type of intermediates in synthesis see: