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Synlett 2019; 30(03): 252-256
DOI: 10.1055/s-0037-1610348
DOI: 10.1055/s-0037-1610348
synpacts
Difunctionalization of the Isocyano Group: Atom-Economic Synthesis of Pyrimidinediones
This work was supported by the NSFC (No. 21772231, 21302220), the Southwest University (No. SWU118129), the Natural Science Foundation of Chongqing (No. cstc2016jcyjA0008), and Fundamental Research Funds for the Central Universities.
Further Information
Publication History
Received: 29 September 2018
Accepted after revision: 12 November 2018
Publication Date:
11 December 2018 (online)
Dedicated to Professor Weiping Su
Abstract
The exploration of synthetic methods involving the formation of new chemical bonds at both the nitrogen and carbons atoms of the isocyano group would largely enrich the structural diversity of compounds. Herein, we disclosed a silver-catalyzed difunctionalization of the isocyano group with cyclic oximes. This method can generate a great array of structurally novel and interesting pyrimidinediones and features excellent atom economy, good functional group compatibility, and amenability to late-stage modifications.
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Reactions involving nitrene insertion into C–M bonds, see: