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CC BY 4.0 · SynOpen 2018; 02(03): 0240-0245
DOI: 10.1055/s-0037-1610216
DOI: 10.1055/s-0037-1610216
psp
Separation of the 5- and 6-Carboxy Regioisomers of ROX and JOE Dyes with Examples of N-(3-Azidopropyl)amide Synthesis
The authors gratefully acknowledge support from the Russian Foundation for Basic Research, grant 18-03-00094-a. Experiments were in part carried out using the equipment provided by the IBCH сore facility (CKP IBCH, supported by Russian Ministry of Education and Science, grant RFMEFI62117X0018).Further Information
Publication History
Received: 23 May 2018
Accepted after revision: 01 July 2018
Publication Date:
25 July 2018 (online)
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Abstract
Despite the widespread applications of various rhodamine and fluorescein 5- and 6-carboxy derivatives, the preparation of their pure regioisomers, in particular cases, remains a complex task. In the present paper we propose optimized approaches to the synthesis and separation of these isomers of ROX and JOE dyes, and also demonstrate their applicability in the synthesis of the corresponding N-(3-azidopropyl)amides.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610216.
- Supporting Information
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