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Synthesis 2018; 50(22): 4429-4434
DOI: 10.1055/s-0037-1610158
DOI: 10.1055/s-0037-1610158
paper
Modular Dihydrobenzoazaphosphole Ligands for Suzuki–Miyaura Cross-Coupling
Further Information
Publication History
Received: 13 March 2018
Accepted after revision: 24 April 2018
Publication Date:
12 June 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201822/lookinside/thumbnails/ss-2018-c0181-st_10-1055_s-0037-1610158-1.jpg)
Dedicated to Professor Scott E. Denmark on the occasion of his 65th birthday
Published as part of the Special Section dedicated to Scott E. Denmark on the occasion of his 65th birthday
Abstract
A new family of dihydrobenzoazaphosphosphole ligands was prepared and shown to enable modification of the phosphine electronic character by variation of the N-substituent. This new family of phosphines was shown to be highly active in the Pd-catalyzed Suzuki–Miyaura cross-coupling reaction with hindered coupling partners.
Key words
dihydrobenzoazaphosphosphole - ligand - N-substituent - palladium - Suzuki–Miyaura cross-couplingSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610158. 1H and 13C NMR data are included.
- Supporting Information
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Reviews:
Examples of synthesis of azaphospholes and their applications, see:
Reviews: