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DOI: 10.1055/s-0037-1610069
A Highly Efficient NHC-Catalyzed Aerobic Oxidation of Aldehydes to Carboxylic Acids
B.T. thanks the Science & Engineering Research Board (SERB), New Delhi, India, for a research grant (EMR/2015/00097).Publication History
Received: 31 March 2018
Accepted after revision: 27 April 2018
Publication Date:
16 July 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201821/lookinside/thumbnails/ss-2018-c0219-st_10-1055_s-0037-1610069-1.jpg)
‡ These authors contributed equally to this work.
Dedicated to Dr. Srivari Chandrasekhar, IICT, Hyderabad, India on his 54th birthday
Published as part of the Special Topic Heterocycles as Catalysts, Ligands, and Targets
Abstract
An N-heterocyclic carbene (NHC) organocatalytic aerobic oxidation of aldehydes to the corresponding carboxylic acids is explored. Remarkably, this method allows for efficient conversion of different classes of aldehydes including highly challenging electron-rich aryl aldehydes, ortho-substituted aryl aldehydes, various heteroaromatic aldehydes and α,β-unsaturated aldehydes under mild reaction conditions. These substrates, under previously reported NHC-catalyzed methods, are typically unreactive or give poor yields, require high reaction temperatures and reaction times of several days.
Key words
carboxylic acids - aldehydes - N-heterocyclic carbenes - aerobic oxidation - organocatalysisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610069.
- Supporting Information
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