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Synthesis 2018; 50(16): 3187-3196
DOI: 10.1055/s-0037-1610023
DOI: 10.1055/s-0037-1610023
special topic
Regio- and Stereoselective Nickel-Catalyzed Coupling of Boronic Acids with Allenoates
Acknowledgment is made to University of Bologna for financial support. Y.L. thanks Chinese Scholarship Council No. 201609120008 for funding support.Weitere Informationen
Publikationsverlauf
Received: 27. März 2018
Accepted after revision: 23. April 2018
Publikationsdatum:
12. Juni 2018 (online)
![](https://www.thieme-connect.de/media/synthesis/201816/lookinside/thumbnails/ss-2018-c0208-st_10-1055_s-0037-1610023-1.jpg)
Published as part of the Special Topic Modern Coupling Approaches and their Strategic Applications in Synthesis
Abstract
The Ni(II)-catalyzed cross-coupling of arylboronic acids with allenoates is documented. The high regio- and stereoselectivity of the process enables a wide range of β-aryl β,γ-unsaturated esters to be prepared in good to excellent yields (up to 95%) and high E/Z-selectivity. Additionally, [3+2]-cascade sequence was observed when 2-formylphenylboronic acid was employed.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610023.
- Supporting Information
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For general reviews on Ni catalysis, see:
For a selection of Ni-catalyzed Suzuki-type cross-coupling, see: