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Synthesis 2018; 50(24): 4905-4914
DOI: 10.1055/s-0037-1609916
DOI: 10.1055/s-0037-1609916
paper
Synthesis of Functionalized 5-Amino-3(2H)-furanones via Base-Catalyzed Ring-Cleavage/Recyclization of 4-Cyano-3(2H)-furanones in the Presence of Water
Further Information
Publication History
Received: 08 June 2018
Accepted after revision: 19 July 2018
Publication Date:
15 August 2018 (online)
Abstract
5-Alkyl/aryl/hetaryl-4-cyano-3(2H)-furanones undergo ring-cleavage/recyclization in the presence of water under mild conditions [MOH (M = Na, K), aqueous ethanol, 20–25 °C] to afford 4-acyl/aroyl/hetaroyl-5-amino-3(2Н)-furanones in 75–99% yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609916.
- Supporting Information
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