The Invention of New Methodologies: An Opportunity for Dating Natural Products

Abstract

This Account surveys almost two decades of methodological developments and their straightforward applications to the total synthesis of simple natural products. The main directions covered include radical chemistry and cascades, electrophilic catalysis based on coinage metals, and asymmetric synthesis based on bis(sulfoxides) auxiliaries.

1 Introduction

2 Radical Cascades

2.1 N-Cyanamides

2.2 Homolytic Substitution at Sulfur Atom to Give Sultines

3 Electrophilic Catalysis Based on Platinum(II) and Gold(I) Complexes

4 From Alkylydene Bis(sulfoxides) to Chiral Carboxylic Acids

5 Conclusion and Perspectives

Key words

radical chemistry - gold catalysis - natural products - total synthesis - asymmetric synthesis - bis(sulfoxides)

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