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Synlett 2018; 29(08): 1037-1042
DOI: 10.1055/s-0037-1609321
DOI: 10.1055/s-0037-1609321
letter
Synthesis of Dihydrospiro Furo[2,3-c]pyrazoles Promoted by Hypervalent Iodine in Water
We are grateful to SERB-DST, New Delhi for financial support (grant no. EEQ/20l6/000066). Ashok is thankful to UGC, New Delhi for SRF.Weitere Informationen
Publikationsverlauf
Received: 07. Dezember 2017
Accepted after revision: 29. Januar 2018
Publikationsdatum:
26. Februar 2018 (online)
![](https://www.thieme-connect.de/media/synlett/201808/lookinside/thumbnails/st-2017-b0881-l_10-1055_s-0037-1609321-1.jpg)
Abstract
A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3-c]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609321.
- Supporting Information
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