Semin Respir Crit Care Med 2017; 38(06): 785-792
DOI: 10.1055/s-0037-1608774
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Multimodality Monitoring: Toward Improved Outcomes

Richard Gandee
1   Internal Medicine, Doctors Hospital, OhioHealth, Columbus, Ohio
,
Chad Miller
2   Riverside Methodist Hospital, OhioHealth, Columbus, Ohio
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2017 (online)

Abstract

Multimodality monitoring provides insights into the critically ill brain-injured patient through the assessment of biochemical, physiological, and electrical data that provides insight into a patient's condition and what strategies may be available to limit further damage and improve the odds for recovery. Modalities utilized include evaluation of intracranial pressure along with cerebral perfusion pressure to determine adequate blood flow; continuous electroencephalography to protect the patient from seizures and to identify early functional manifestations of ischemia and toxicity; transcranial Doppler evaluation for bedside review of circulatory adequacy; tissue oxygen monitoring to establish that brain tissue is receiving adequate oxygen from blood flow; and microdialysis to evaluate the metabolic function of the tissue in areas of concern. These monitors provide insights regarding specific aspects of brain tissue and overall brain function in the critically ill patient. Although recommendations continue to evolve for therapeutic targets for each of these modalities, an effective clinician may use each of these modalities to evaluate patients on an individual basis to improve the outcome of each patient, tailoring management to provide the care needed for any unique clinical presentation.

 
  • References

  • 1 Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology 2001; 56 (12) 1746-1748
  • 2 Le Roux P, Menon DK, Citerio G. , et al. Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care: a statement for healthcare professionals from the Neurocritical Care Society and the European Society of Intensive Care Medicine. Neurocrit Care 2014; 21 (Suppl. 02) S1-S26
  • 3 Tasneem N, Samaniego EA. , et al. Brain multimodality monitoring: a new tool in neurocritical care of comatose patient. Crit Care Res Pract Vol 2017; 2017: 6097265
  • 4 Roh D, Park S. Brain multimodality monitoring: updated perspectives. Curr Neurol Neurosci Rep 2016; 16 (06) 56
  • 5 Kristiansson H, Nissborg E, Bartek Jr J, Andresen M, Reinstrup P, Romner B. Measuring elevated intracranial pressure through noninvasive methods: a review of the literature. J Neurosurg Anesthesiol 2013; 25 (04) 372-385
  • 6 Brain Trauma Foundation; American Association of Neurological Surgeons; Congress of Neurological Surgeons; Joint Section on Neurotrauma and Critical Care, AANS/CNS. Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology. J Neurotrauma 2007; 24 (1, suppl 1): S45-S54
  • 7 Nordström C-H, Koskinen L-O, Olivecrona M. Aspects on the physiological and biochemical foundations of neurocritical care. Front Neurol 2017; 8: 274
  • 8 Rosner MJ, Rosner SD, Johnson AH. Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg 1995; 83 (06) 949-962
  • 9 Brain Trauma Foundation. “Guidelines for Management of Severe Traumatic Brain Injury” 4th edition, 2016 . Available at: http://braintrauma.org/ coma/guidelines . Accessed on March 8, 2017
  • 10 Andrews PJ, Sleeman DH, Statham PF. , et al. Predicting recovery in patients suffering from traumatic brain injury by using admission variables and physiological data: a comparison between decision tree analysis and logistic regression. J Neurosurg 2002; 97 (02) 326-336
  • 11 Sviri GE, Aaslid R, Douville CM, Moore A, Newell DW. Time course for autoregulation recovery following severe traumatic brain injury. J Neurosurg 2009; 111 (04) 695-700
  • 12 Contant CF, Valadka AB, Gopinath SP, Hannay HJ, Robertson CS. Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury. J Neurosurg 2001; 95 (04) 560-568
  • 13 Gerber LM, Chiu YL, Carney N, Härtl R, Ghajar J. Marked reduction in mortality in patients with severe traumatic brain injury. J Neurosurg 2013; 119 (06) 1583-1590
  • 14 Jones S, Schwartzbauer G, Jia X. Brain monitoring in critically neurologically impaired patients. Int J Mol Sci 2016; 18 (01) 43
  • 15 Chesnut RM, Temkin N, Carney N. , et al; Global Neurotrauma Research Group. A trial of intracranial-pressure monitoring in traumatic brain injury. N Engl J Med 2012; 367 (26) 2471-2481
  • 16 Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S. ; Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2006; 67 (02) 203-210
  • 17 Friedman D, Claassen J, Hirsch LJ. Continuous electroencephalogram monitoring in the intensive care unit. Anesth Analg 2009; 109 (02) 506-523
  • 18 Rossetti AO, Oddo M. The neuro-ICU patient and electroencephalography paroxysms: if and when to treat. Curr Opin Crit Care 2010; 16 (02) 105-109
  • 19 Kull LL, Emerson RG. Continuous EEG monitoring in the intensive care unit: technical and staffing considerations. J Clin Neurophysiol 2005; 22 (02) 107-118
  • 20 Hirsch LJ. Continuous EEG monitoring in the intensive care unit: an overview. J Clin Neurophysiol 2004; 21 (05) 332-340
  • 21 Roh DJ, Morris NA, Claassen J. Intracranial multimodality monitoring for delayed cerebral ischemia. J Clin Neurophysiol 2016; 33 (03) 241-249
  • 22 Waziri A, Claassen J, Stuart RM. , et al. Intracortical electroencephalography in acute brain injury. Ann Neurol 2009; 66 (03) 366-377
  • 23 Claassen J, Perotte A, Albers D. , et al. Nonconvulsive seizures after subarachnoid hemorrhage: multimodal detection and outcomes. Ann Neurol 2013; 74 (01) 53-64
  • 24 Claassen J, Vespa P. ; Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring. Electrophysiologic monitoring in acute brain injury. Neurocrit Care 2014; 21 (Suppl. 02) S129-S147
  • 25 Stuart RM, Schmidt M, Kurtz P. , et al. Intracranial multimodal monitoring for acute brain injury: a single institution review of current practices. Neurocrit Care 2010; 12 (02) 188-198
  • 26 Hofmeijer J, Beernink TM, Bosch FH, Beishuizen A, Tjepkema-Cloostermans MC, van Putten MJ. Early EEG contributes to multimodal outcome prediction of postanoxic coma. Neurology 2015; 85 (02) 137-143
  • 27 Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology 2004; 62 (10) 1743-1748
  • 28 Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol 2004; 61 (07) 1090-1094
  • 29 Sundt Jr TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick Jr JM, O'Fallon WM. Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc 1981; 56 (09) 533-543
  • 30 Jordan KG. Emergency EEG and continuous EEG monitoring in acute ischemic stroke. J Clin Neurophysiol 2004; 21 (05) 341-352
  • 31 Simmons LE, Riker RR, Prato BS, Fraser GL. Assessing sedation during intensive care unit mechanical ventilation with the Bispectral Index and the Sedation-Agitation Scale. Crit Care Med 1999; 27 (08) 1499-1504
  • 32 Abou Khaled KJ, Hirsch LJ. Updates in the management of seizures and status epilepticus in critically ill patients. Neurol Clin 2008; 26 (02) 385-408 , viii
  • 33 Winer JW, Rosenwasser RH, Jimenez F. Electroencephalographic activity and serum and cerebrospinal fluid pentobarbital levels in determining the therapeutic end point during barbiturate coma. Neurosurgery 1991; 29 (05) 739-741 , discussion 741–742
  • 34 Rossetti AO, Urbano LA, Delodder F, Kaplan PW, Oddo M. Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest. Crit Care 2010; 14 (05) R173
  • 35 Kassab MY, Majid A, Farooq MU. , et al. Transcranial Doppler: an introduction for primary care physicians. J Am Board Fam Med 2007; 20 (01) 65-71
  • 36 Vora YY, Suarez-Almazor M, Steinke DE, Martin ML, Findlay JM. Role of transcranial Doppler monitoring in the diagnosis of cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery 1999; 44 (06) 1237-1247 , discussion 1247–1248
  • 37 Proust F, Callonec F, Clavier E. , et al. Usefulness of transcranial color-coded sonography in the diagnosis of cerebral vasospasm. Stroke 1999; 30 (05) 1091-1098
  • 38 Bellner J, Romner B, Reinstrup P, Kristiansson KA, Ryding E, Brandt L. Transcranial Doppler sonography pulsatility index (PI) reflects intracranial pressure (ICP). Surg Neurol 2004; 62 (01) 45-51 , discussion 51
  • 39 Feri M, Ralli L, Felici M, Vanni D, Capria V. Transcranial Doppler and brain death diagnosis. Crit Care Med 1994; 22 (07) 1120-1126
  • 40 Macmillan CS, Andrews PJ. Cerebrovenous oxygen saturation monitoring: practical considerations and clinical relevance. Intensive Care Med 2000; 26 (08) 1028-1036
  • 41 White H, Baker A. Continuous jugular venous oximetry in the neurointensive care unit--a brief review. Can J Anaesth 2002; 49 (06) 623-629
  • 42 Cruz J. On-line monitoring of global cerebral hypoxia in acute brain injury. Relationship to intracranial hypertension. J Neurosurg 1993; 79 (02) 228-233
  • 43 Cormio M, Valadka AB, Robertson CS. Elevated jugular venous oxygen saturation after severe head injury. J Neurosurg 1999; 90 (01) 9-15
  • 44 Al-Rawi PG, Smielewski P, Kirkpatrick PJ. Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 2001; 32 (11) 2492-2500
  • 45 Stiefel MF, Udoetuk JD, Spiotta AM. , et al. Conventional neurocritical care and cerebral oxygenation after traumatic brain injury. J Neurosurg 2006; 105 (04) 568-575
  • 46 Gupta AK, Hutchinson PJ, Al-Rawi P. , et al. Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury. Anesth Analg 1999; 88 (03) 549-553
  • 47 Pfeifer R, Ferrari M, Börner A, Deufel T, Figulla HR. Serum concentration of NSE and S-100b during LVAD in non-resuscitated patients. Resuscitation 2008; 79 (01) 46-53
  • 48 Wolf H, Krall C, Pajenda G. , et al. Preliminary findings on biomarker levels from extracerebral sources in patients undergoing trauma surgery: potential implications for TBI outcome studies. Brain Inj 2016; 30 (10) 1220-1225
  • 49 Brandner S, Thaler C, Buchfelder M, Kleindienst A. Brain-derived protein concentrations in the cerebrospinal fluid: contribution of trauma resulting from ventricular drain insertion. J Neurotrauma 2013; 30 (13) 1205-1210
  • 50 Ungerstedt U, Rostami E. Microdialysis in neurointensive care. Curr Pharm Des 2004; 10 (18) 2145-2152
  • 51 Dreier JP, Major S, Manning A. , et al; COSBID study group. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 2009; 132 (Pt 7): 1866-1881
  • 52 Tseng EE, Brock MV, Lange MS. , et al. Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg 2010; 89 (02) 440-445
  • 53 Nordmark J, Rubertsson S, Mörtberg E, Nilsson P, Enblad P. Intracerebral monitoring in comatose patients treated with hypothermia after a cardiac arrest. Acta Anaesthesiol Scand 2009; 53 (03) 289-298
  • 54 Antunes AP, Schiefecker AJ, Beer R. , et al. Higher brain extracellular potassium is associated with brain metabolic distress and poor outcome after aneurysmal subarachnoid hemorrhage. Crit Care 2014; 18 (03) R119
  • 55 Nilsson OG, Brandt L, Ungerstedt U, Säveland H. Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration. Neurosurgery 1999; 45 (05) 1176-1184 , discussion 1184–1185
  • 56 Misini B, Freinbichler W, Colivicchi MA. , et al. Continuous monitoring of highly reactive oxygen radicals during in vivo microdialysis. J Neurosci Methods 2015; 251: 1-6
  • 57 Helbok R, Schiefecker AJ, Beer R. , et al. Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study. Crit Care 2015; 19: 75