RSS-Feed abonnieren
DOI: 10.1055/s-0037-1608708
Perianal Dermatitis, Its Incidence, and Patterns of Topical Therapies in a Level IV Neonatal Intensive Care Unit
Publikationsverlauf
04. Juli 2017
09. Oktober 2017
Publikationsdatum:
22. November 2017 (online)
Abstract
Objective To define the incidence of perianal dermatitis (PD) and determine the usage pattern and cost efficacy of diaper products among neonates admitted to a level IV neonatal intensive care unit (NICU) including those with a diagnosis of neonatal abstinence syndrome (NAS).
Methods A retrospective cohort study to evaluate neonates with PD based on number of orders for Aquaphor, Bagbalm, Desitin, Flanders, or Nystatin. Various demographic and clinical parameters were recorded. Usage patterns of these five products were analyzed, and their costs estimated. Subgroup analysis was performed among infants with NAS.
Results Of 1,241 admissions, 56.2% had at least one diaper product ordered during their NICU stay, while 52.6% had multiple products ordered. Only 23.0% of all neonates had appropriate documentation of PD. The most common product ordered first was Aquaphor (64.3%), followed by Desitin (19.2%). Note that 86% term NAS infants had PD compared with 28% term non-NAS infants. The estimated product cost was $14,139 over 2 years, averaging $20 per patient.
Conclusion Over half of NICU neonates were exposed to one or more diaper products, usually without documented PD diagnosis. Term NAS infants had three times higher incidence of PD than term non-NAS infants. The cost of diaper product use was significant, and possibly underestimated due to lack of documentation.
-
References
- 1 Coughlin CC, Eichenfield LF, Frieden IJ. Neonatal Dermatology. Philadelphia, PA: Saunders Elsevier; 2008
- 2 Blume-Peytavi U, Hauser M, Lünnemann L, Stamatas GN, Kottner J, Garcia Bartels N. Prevention of diaper dermatitis in infants--a literature review. Pediatr Dermatol 2014; 31 (04) 413-429
- 3 Berg RW, Buckingham KW, Stewart RL. Etiologic factors in diaper dermatitis: the role of urine. Pediatr Dermatol 1986; 3 (02) 102-106
- 4 Buckingham KW, Berg RW. Etiologic factors in diaper dermatitis: the role of feces. Pediatr Dermatol 1986; 3 (02) 107-112
- 5 Cork MJ, Danby SG, Vasilopoulos Y. , et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 2009; 129 (08) 1892-1908
- 6 Fluhr JW, Darlenski R, Taieb A. , et al. Functional skin adaptation in infancy - almost complete but not fully competent. Exp Dermatol 2010; 19 (06) 483-492
- 7 Stamatas GN, Nikolovski J, Mack MC, Kollias N. Infant skin physiology and development during the first years of life: a review of recent findings based on in vivo studies. Int J Cosmet Sci 2011; 33 (01) 17-24
- 8 Shin HT. Diaper dermatitis that does not quit. Dermatol Ther (Heidelb) 2005; 18 (02) 124-135
- 9 Visscher M, Odio M, Taylor T. , et al. Skin care in the NICU patient: effects of wipes versus cloth and water on stratum corneum integrity. Neonatology 2009; 96 (04) 226-234
- 10 Afsar FS. Skin care for preterm and term neonates. Clin Exp Dermatol 2009; 34 (08) 855-858
- 11 El-Hodhod MA, Hamdy AM, El-Deeb MT, Elmaraghy MO. Cow's milk allergy is a major contributor in recurrent perianal dermatitis of infants. ISRN Pediatr 2012; 2012: 408769
- 12 Wright JE, Butt HL. Perianal infection with beta haemolytic streptococcus. Arch Dis Child 1994; 70 (02) 145-146
- 13 Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM. Diaper dermatitis: frequency and severity among a general infant population. Pediatr Dermatol 1986; 3 (03) 198-207
- 14 Pratt AG, Read Jr WT. Influence of type of feeding on pH of stool, pH of skin, and incidence of perianal dermatitis in the newborn infant. J Pediatr 1955; 46 (05) 539-543
- 15 Lundov MD, Krongaard T, Menné TL, Johansen JD. Methylisothiazolinone contact allergy: a review. Br J Dermatol 2011; 165 (06) 1178-1182
- 16 Ness MJ, Davis DM, Carey WA. Neonatal skin care: a concise review. Int J Dermatol 2013; 52 (01) 14-22
- 17 Philipp R, Hughes A, Golding J. ; ALSPAC Survey Team. Avon Longitudinal Study of Pregnancy and Childhood. Getting to the bottom of nappy rash. Br J Gen Pract 1997; 47 (421) 493-497
- 18 Philipp R, Hughes A, Golding J. ; ALSPAC Survey Team. Avon Longitudinal Study of Pregnancy and Childhood. Getting to the bottom of nappy rash. Br J Gen Pract 1997; 47 (421) 493-497
- 19 Furber C, Bedwell C, Campbell M. , et al. The challenges and realties of diaper area cleansing for parents. J Obstet Gynecol Neonatal Nurs 2012; 41 (06) E13-E25
- 20 Liu N, Wang X, Odio M. Frequency and severity of diaper dermatitis with use of traditional Chinese cloth diapers: observations in 3- to 9-month-old children. Pediatr Dermatol 2011; 28 (04) 380-386
- 21 Lund CH, Kuller J, Lane AT, Lott JW, Raines DA, Thomas KK. Neonatal skin care: evaluation of the AWHONN/NANN research-based practice project on knowledge and skin care practices. Association of Women's Health, Obstetric and Neonatal Nurses/National Association of Neonatal Nurses. J Obstet Gynecol Neonatal Nurs 2001; 30 (01) 30-40
- 22 Lund CH, Osborne JW, Kuller J, Lane AT, Lott JW, Raines DA. Neonatal skin care: clinical outcomes of the AWHONN/NANN evidence-based clinical practice guideline. Association of Women's Health, Obstetric and Neonatal Nurses and the National Association of Neonatal Nurses. J Obstet Gynecol Neonatal Nurs 2001; 30 (01) 41-51
- 23 Lam J, Pope E. Case 1: a ‘rash’-ional approach to recalcitrant diaper dermatitis. Paediatr Child Health 2007; 12 (02) 129-131
- 24 Gunes T, Akin MA, Sarici D, Hallac K, Kurtoglu S, Hashimoto T. Guaiazulene: a new treatment option for recalcitrant diaper dermatitis in NICU patients. J Matern Fetal Neonatal Med 2013; 26 (02) 197-200
- 25 Jones HE, Kaltenbach K, Heil SH. , et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med 2010; 363 (24) 2320-2331
- 26 Finnegan LP, Kaltenbach K. Neonatal abstinence syndrome. In: Hoekelman RA, Friedman SB, Nelson NM. , et al., eds. Primary Pediatric Care. 2nd ed. St. Louis: Mosby; 1992: 1367-1378
- 27 Finnegan LP, Hagan T, Kaltenbach KA. Scientific foundation of clinical practice: opiate use in pregnant women. Bull N Y Acad Med 1991; 67 (03) 223-239
- 28 Kocherlakota P. Neonatal abstinence syndrome. Pediatrics 2014; 134 (02) e547-e561
- 29 Atherton DJ. A review of the pathophysiology, prevention and treatment of irritant diaper dermatitis. Curr Med Res Opin 2004; 20 (05) 645-649
- 30 Bagwell G, Thomas A, Ryshen G. Improving Skin Integrity in Babies diagnosed with Neonatal Abstinence Syndrome. Neonatal Netw 2016; 35 (05) 1-7
- 31 Nanda S, Brant R, Regier M, Yossuck P. Buprenorphine: a new player in neonatal withdrawal syndrome. W V Med J 2015; 111 (01) 16-21
- 32 Cohen B. Differential diagnosis of diaper dermatitis. Clin Pediatr (Phila) 2017; 56 (5_suppl, 5S): 16S-22S
- 33 Gaalema DE, Scott TL, Heil SH. , et al. Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. Addiction 2012; 107 (Suppl. 01) 53-62