Planta Medica International Open 2017; 4(S 01): S1-S202
DOI: 10.1055/s-0037-1608487
Poster Session
Georg Thieme Verlag KG Stuttgart · New York

Bioavailability study and impact of Chios mastic supplementation on oxidative stress in healthy humans

V Brieudes
1   Divisionof Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
,
E Kallergis
1   Divisionof Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
,
E Papada
2   Laboratory of Food Chemistry-Biochemistry, School of Health Science and Education, Department of Dietetics and Nutritional Science, Athens, Greece
,
A Gioxari
2   Laboratory of Food Chemistry-Biochemistry, School of Health Science and Education, Department of Dietetics and Nutritional Science, Athens, Greece
,
A Kaliora
2   Laboratory of Food Chemistry-Biochemistry, School of Health Science and Education, Department of Dietetics and Nutritional Science, Athens, Greece
,
S Mitakou
1   Divisionof Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
,
L Skaltsounis
1   Divisionof Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
,
M Halabalaki
1   Divisionof Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2017 (online)

 

Chios mastic, is the resinous secretion obtained from the wounds of the trunk and branches of Pistacia lentiscus L. var. Chia, which is endemic to the Greek island of Chios. Traditional usage of mastic dates back to more than 2500 years for gastrointestinal disorders [1]. More recently, mastic showed promising results in active Crohn's disease patients [2] as well as lipid- and glucose-lowering properties [3], antioxidant and anti-inflammatory properties [4]. In this work, 17 healthy volunteers were participated receiving per os a single dose of Chios mastic. Blood samples were collected at specific time intervals (e.g. 0, 1, 2, 4, 6 and 24 hours). After pretreatment plasma samples were analyzed by UHPLC-tQ-MS and the main constituents namely isomasticadienonic acid (IMNA) and masticadienonic acid (MNA) were directly quantified. MNA and IMNA are the most characteristic triterpenic acids of Chios mastic resin. Both compounds are not commercially available and have been isolated by an SFC-MS based method newly developed in house. MNA and IMNA were detected and Cmax plasma values were ranging from 29 to 768 ng/mL for IMNA and from 52 to 1390 ng/mL for MNA. Maximum concentration times were different depending on the subjects between 2 and 4 hours after intake. Moreover, oxidative stress markers in a postprandial phase were evaluated. Serum resistance time to oxidation increased after intake while the same trend was observed regarding the % change in oxLDL. This study offers for the first time information on the availability of bioactive components following ingestion of Chios mastic in humans together with evidence of its potency for oxidative stress reduction.

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[2] A.C. Kaliora et al., World J. Gastroenterol. 2007, 13, 748 – 753.

[3] A. Kartalis et al., Eur J Prev Cardiol. 2016, 23, 722 – 729.

[4] A.N. Assimopoulou et al., Food Chemistry. 2005, 92, 721 – 727.