Association of 3q26 Genes with Tumor Volume, Tumor Recurrence Pattern, and Overall Survival in Glioblastoma Patients

Aim: SOX2 and OPA1 genes co-locate at 3q26 and regulate glioma invasion. We aim at testing whether copy number variations of these genes impact overall survival (OS), tumor volume and tumor recurrence pattern in glioblastoma (GBM) patients.

Methods: Biopsies from 64 GBM patients operated between 2009 and 2014 were analyzed for SOX2 and OPA1 copy number variations. Demographic, tumor volumetric data from the preoperative magnetic resonance images (MRI) and tumor recurrence patterns from the follow up MRIs were collected from the same patients. Association between genetic, survival and imaging data in GBM will be investigated by appropriate survival analysis methods (e.g., multivariable Cox proportional hazard models).

Results: The majority of patients were male (39 thus 61%) and the median age at the day of surgery was 63 years (interquartile range (IQR) 56 to 70 years). Twenty-two out of 64 patients (34.4%) showed an amplification of SOX2 and 10 patients (15.6%) a deletion of OPA1. Median survival was 404 days (CI 316–482) days and during follow up 59 (92%) patients died. Fifty of the patients (78.1%) had a documented tumor recurrence or progress during follow up. Median preoperative enhancing tumor volume was 18.2 ml (IQR 8.2 to 41.7) and median postoperative remnant tumor volume was 1% (IQR 0% to 43%).

Initial results from survival analysis will be presented and generated evidence will be discussed.

Conclusions: Conclusion will be presented together with the initial results.