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Semin Thromb Hemost 2017; 43(06): 621-628
DOI: 10.1055/s-0037-1603358
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Serum Concentration of Growth Differentiation Factor-15 Is Independently Associated with Global Platelet Function and Higher Fibrinogen Values in Adult Healthy Subjects

Giuseppe Lippi
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Gian Luca Salvagno
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Elisa Danese
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Giorgio Brocco
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Matteo Gelati
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Martina Montagnana
1   Section of Clinical Biochemistry, University of Verona, Verona, Italy
,
Fabian Sanchis-Gomar
2   Department of Physiology, Instituto de Investigación INCLIVA, University of Valencia and Fundación Investigación Hospital Clínico Universitario de Valencia, Valencia, Spain
3   Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York
,
Emmanuel J. Favaloro
4   Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, Australia
› Author Affiliations
Further Information

Publication History

Publication Date:
08 June 2017 (online)

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Abstract

Growth differentiation factor-15 (GDF-15) has recently emerged as a strong and independent predictor of cardiovascular events and mortality. However, the pathophysiological mechanisms underlying this important association remain speculative. This study was aimed to investigate the potential associations between the serum concentration of GDF-15 and clinical or laboratory parameters in a population of ostensibly healthy subjects. The study population consisted of 44 healthy volunteers enrolled from the laboratory staff (14 males and 30 females; mean age, 47 ± 11 years), who had their blood collected for assessing complete blood cell count, GDF-15, serum creatinine, albumin, cardiac troponin T, galectin-3, routine coagulation tests, D-dimer, von Willebrand factor, and platelet function testing using platelet function analyzer-100. In univariate analysis, serum GDF-15 was found to be positively associated with age and plasma fibrinogen, and negatively associated with renal function and collagen-epinephrine (CEPI). In multiple linear regression analysis, serum GDF-15 remained significantly associated with renal function, CEPI, and plasma fibrinogen. Healthy subjects with GDF-15 above the median value had a twofold probability of displaying shorter CEPI closure times. Taken together, these results suggest that higher serum values of GDF-15 may be associated with overall global platelet hyperactivity and increased plasma fibrinogen, so providing another plausible explanation for the association between GDF-15, cardiovascular events, and mortality.

Keywords

growth differentiation factor-15 - GDF-15 - cardiovascular disease - platelets - PFA-100
 

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