Download PDF
Facial Plast Surg 2017; 33(03): 339-346
DOI: 10.1055/s-0037-1602164
Rapid Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effects of Tumescent Solution on Fat Survival

Hakan Sirinoglu
1   Department of Plastic, Reconstructive and Aesthetic Surgery, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Cevizli, Istanbul, Turkey
,
Nebil Yesiloglu
1   Department of Plastic, Reconstructive and Aesthetic Surgery, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Cevizli, Istanbul, Turkey
,
Özlem Tuğçe Kaya
2   Department of Histology, Marmara Universitesi Ringgold Standard İnstitution, Istanbul, Istanbul, Turkey
,
Feriha Ercan
2   Department of Histology, Marmara Universitesi Ringgold Standard İnstitution, Istanbul, Istanbul, Turkey
,
Gaye Taylan Filinte
1   Department of Plastic, Reconstructive and Aesthetic Surgery, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Cevizli, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
01 June 2017 (online)

Also available at
    Permissions and Reprints

Corrected by:

Erratum: Effects of Tumescent Solution on Fat SurvivalFacial Plast Surg 2017; 33(04): 457-458
DOI: 10.1055/s-0037-1604164

Abstract

Autologous fat transfer is a commonly used procedure in plastic surgery practice. The long-term survival rate of fat grafts is the most important issue for satisfactory results. The presented study includes the effects of different tumescent solutions on long-term fat graft survival. A total of 24 rats were divided into four groups: sham, lidocaine, adrenaline, and lidocaine + adrenaline groups. In all groups except the sham group, right inguinal fat pad was harvested 10 minutes after injecting 5 cc of the appropriate tumescent solution. The fat pad was trimmed and reimplanted to the interscapular area. After 3 months, fat pad was reharvested and sent for histopathologic evaluation. The harvested fat grafts were weighted in both surgical sessions. A significant difference was observed in comparison of fat grafts weights between the initial operation and the postoperative third month (p = 0.002). By intergroup comparisons, a significant difference was observed between sham and adrenaline groups (p = 0.002) and between sham and lidocaine + adrenaline groups (p = 0.007). No statistical difference was observed by the comparison of TUNNEL results (p = 0.663). The histopathologic evaluation of the specimens revealed similar results between groups. The injection of tumescent solutions containing only lidocaine before fat harvesting yields similar long-term fat graft survival rates in comparison to the conduction of surgical procedure without injecting any tumescent fluid. However, the injection of solutions containing adrenaline with or without lidocaine may decrease the long-term survival rates of fat autografts.

Keywords

liposuction - autologous fat transfer - tumescent solution - fat graft survival
 

  • References

  • 1 Coleman SR. Structural fat grafting. Aesthet Surg J 1998; 18 (05) 386-388 , 388
    CrossrefPubMedGoogle Scholar
  • 2 Smith P, Adams Jr WP, Lipschitz AH. , et al. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg 2006; 117 (06) 1836-1844
    CrossrefPubMedGoogle Scholar
  • 3 Paolini G, Amoroso M, Longo B, Sorotos M, Karypidis D, Santanelli di Pompeo F. Simplified lipostructure: a technical note. Aesthetic Plast Surg 2014; 38 (01) 78-82
    CrossrefPubMedGoogle Scholar
  • 4 Burk III RW, Guzman-Stein G, Vasconez LO. Lidocaine and epinephrine levels in tumescent technique liposuction. Plast Reconstr Surg 1996; 97 (07) 1379-1384
    CrossrefPubMedGoogle Scholar
  • 5 Marten TJ, Elyassnia D. Fat grafting in facial rejuvenation. Clin Plast Surg 2015; 42 (02) 219-252
    CrossrefPubMedGoogle Scholar
  • 6 Bae YC, Park TS, Kang GB, Nam SB, Bae SH. Usefulness of microfat grafting in patients with repaired cleft lip. J Craniofac Surg 2016; 27 (07) 1722-1726
    CrossrefPubMedGoogle Scholar
  • 7 Mojallal A, Lequeux C, Shipkov C. , et al. Improvement of skin quality after fat grafting: clinical observation and an animal study. Plast Reconstr Surg 2009; 124 (03) 765-774
    CrossrefPubMedGoogle Scholar
  • 8 Strong AL, Cederna PS, Rubin JP, Coleman SR, Levi B. The current state of fat grafting: a review of harvesting, processing, and injection techniques. Plast Reconstr Surg 2015; 136 (04) 897-912
    CrossrefPubMedGoogle Scholar
  • 9 Kaufman MR, Bradley JP, Dickinson B. , et al. Autologous fat transfer national consensus survey: trends in techniques for harvest, preparation, and application, and perception of short- and long-term results. Plast Reconstr Surg 2007; 119 (01) 323-331
    CrossrefPubMedGoogle Scholar
  • 10 Buckingham ED. Fat transfer techniques: general concepts. Facial Plast Surg 2015; 31 (01) 22-28
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Bozkurt M, Kapı E, Şirinoğlu H, Güvercin E, Filinte GT, Filinte D. The effects of the centrifugation speed on the survival of autogenous fat grafts in a rat model. J Plast Surg Hand Surg 2016; 50 (03) 161-166
    CrossrefPubMedGoogle Scholar
  • 12 Wang Q, Guo X, Wang J. Autogenous fat grafting for chin augmentation: a preliminarily clinical study of cosmetic outcome. J Craniofac Surg 2015; 26 (07) e625-e627
    CrossrefPubMedGoogle Scholar
  • 13 Erol OO. Microfat grafting in nasal surgery. Aesthet Surg J 2014; 34 (05) 671-686
    CrossrefPubMedGoogle Scholar
  • 14 Gupta R, Brace M, Taylor SM, Bezuhly M, Hong P. In search of the optimal processing technique for fat grafting. J Craniofac Surg 2015; 26 (01) 94-99
    CrossrefPubMedGoogle Scholar
  • 15 Pu LL, Coleman SR, Cui X, Ferguson Jr RE, Vasconez HC. Autologous fat grafts harvested and refined by the Coleman technique: a comparative study. Plast Reconstr Surg 2008; 122 (03) 932-937
    CrossrefPubMedGoogle Scholar
  • 16 Livaoğlu M, Buruk CK, Uraloğlu M. , et al. Effects of lidocaine plus epinephrine and prilocaine on autologous fat graft survival. J Craniofac Surg 2012; 23 (04) 1015-1018
    CrossrefPubMedGoogle Scholar
  • 17 Önel D, Emekli U, Çizmeci MO. , et al. Review of fat grafting and the fate of the subperiosteal fat graft. Eur J Plast Surg 2013; 26: 169-174
    PubMedGoogle Scholar
  • 18 Guerrerosantos J, Gonzalez-Mendoza A, Masmela Y, Gonzalez MA, Deos M, Diaz P. Long-term survival of free fat grafts in muscle: an experimental study in rats. Aesthetic Plast Surg 1996; 20 (05) 403-408
    CrossrefPubMedGoogle Scholar
  • 19 Locke MB, de Chalain TM. Current practice in autologous fat transplantation: suggested clinical guidelines based on a review of recent literature. Ann Plast Surg 2008; 60 (01) 98-102
    CrossrefPubMedGoogle Scholar
  • 20 Rose Jr JG, Lucarelli MJ, Lemke BN. , et al. Histologic comparison of autologous fat processing methods. Ophthal Plast Reconstr Surg 2006; 22 (03) 195-200
    CrossrefPubMedGoogle Scholar
  • 21 Missana MC, Laurent I, Barreau L, Balleyguier C. Autologous fat transfer in reconstructive breast surgery: indications, technique and results. Eur J Surg Oncol 2007; 33 (06) 685-690
    CrossrefPubMedGoogle Scholar
  • 22 Vargas CR, Iorio ML, Lee BT. A systematic review of topical vasodilators for the treatment of intraoperative vasospasm in reconstructive microsurgery. Plast Reconstr Surg 2015; 136 (02) 411-422
    CrossrefPubMedGoogle Scholar
  • 23 Harrison BL, Malafa M, Davis K, Rohrich RJ. The discordant histology of grafted fat: a systematic review of the literature. Plast Reconstr Surg 2015; 135 (03) 542e-555e
    CrossrefPubMedGoogle Scholar