CC BY-NC-ND 4.0 · J Neurol Surg Rep 2017; 78(02): e68-e70
DOI: 10.1055/s-0037-1598115
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Malignant Peripheral Nerve Sheath Tumor of the C2 Nerve Root: Case Report

Joshua D. Burks
1   Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Robert G. Briggs
1   Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Chad A. Glenn
1   Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
John C. Greenert
2   Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Cordell M. Baker
1   Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Keren Bartal
3   Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Greg A. Krempl
3   Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
,
Michael E. Sughrue
1   Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
› Author Affiliations
Further Information

Publication History

19 August 2016

21 December 2016

Publication Date:
13 April 2017 (online)

Abstract

Here we present the case of a 36-year-old man who was found to have a symptomatic malignant neural sheath tumor growing from the C2 nerve root following a period of progressively worsening headaches. The patient was successfully treated with surgical resection resulting in resolution of cranial nerve deficits. Though uncommon, malignant peripheral nerve sheath tumor must be considered in the differential diagnosis of tumors involving the cervical nerve roots and carotid space.

 
  • References

  • 1 Stucky CC, Johnson KN, Gray RJ. , et al. Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience. Ann Surg Oncol 2012; 19 (03) 878-885
  • 2 Thway K, Fisher C. Malignant peripheral nerve sheath tumor: pathology and genetics. Ann Diagn Pathol 2014; 18 (02) 109-116
  • 3 Gachiani J, Kim D, Nelson A, Kline D. Surgical management of malignant peripheral nerve sheath tumors. Neurosurg Focus 2007; 22 (06) E13
  • 4 Anghileri M, Miceli R, Fiore M. , et al. Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution. Cancer 2006; 107 (05) 1065-1074
  • 5 Wong WW, Hirose T, Scheithauer BW, Schild SE, Gunderson LL. Malignant peripheral nerve sheath tumor: analysis of treatment outcome. Int J Radiat Oncol Biol Phys 1998; 42 (02) 351-360
  • 6 Moretti VM, Crawford EA, Staddon AP, Lackman RD, Ogilvie CM. Early outcomes for malignant peripheral nerve sheath tumor treated with chemotherapy. Am J Clin Oncol 2011; 34 (04) 417-421
  • 7 Winslow N, Abode-Iyamah K, Kirby P, Smith M, Reddy C. Malignant peripheral nerve sheath tumor arising in the setting of cervical nerve root schwannomas. J Clin Neurosci 2015; 22 (10) 1696-1699
  • 8 Voorhies J, Hattab EM, Cohen-Gadol AA. Malignant peripheral nerve sheath tumor of the abducens nerve and a review of the literature. World Neurosurg 2013; 80 (05) 654.e1-654.e8
  • 9 Mautner VF, Friedrich RE, von Deimling A. , et al. Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. Neuroradiology 2003; 45 (09) 618-625
  • 10 King AA, Debaun MR, Riccardi VM, Gutmann DH. Malignant peripheral nerve sheath tumors in neurofibromatosis 1. Am J Med Genet 2000; 93 (05) 388-392