Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596878
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

In vivo anti-inflammatory and hepatoprotective of aerial part of Silene villosa

HS Yusufoglu
1   Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA
,
AI Foudah
1   Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA
,
A Alam
1   Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA
,
GA Soliman
2   Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj, KSA
3   Department of Pharmacology, College of Veterinary Medicine, Cairo University, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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Silene villosa Forssk. (Caryophyllaceae), traditionally used for wound healing and experimentally suggested for cytotoxic effect [1 – 4]. There is little information about their biological activity. The aim was to investigate the anti-inflammatory against carrageenan induced hind paw edema and the hepatoprotective activity against CCl4 intoxication induced hepatotoxicity of methanolic extract of the herbs of S. villosa (MESV).The result of the Methanolic extract of S. villosa (MESV) at both the doses (250 – 500 mg/kg) were showed significant (P< 0.01 – 0.001) anti-inflammatory effect. The MESV, at higher dose, significantly (P < 0.01) normalized the abnormal levels of serum biochemical parameters such as SGOT, SGPT, GGT, ALP, total bilirubin and also significantly (p< 0.01) increased the level of total protein when compared to carbon tetrachloride (CCl4) toxic rats. However, CCl4 intoxication changed the normal malondialdehyde (MDA) and nonprotein sulfhydryls (NP-SH) levels in liver tissues. These changes were also normalized with MESV, indicating the hepatoprotective nature of S. villosa methanolic extract. The hepatoprotective character was further confirmed by the histopathological examination of liver tissues. The present findings show that MESV holds the anti-inflammatory and hepatoprotective properties.

Keywords: Antiinflammatory effect, hepatoprotective effect, Silene villosa, biochemical parameters, histopathology.

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