Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596635
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Steroids and cembranoids from the soft corals Nephthea erecta and Lobophytum crissum

JH Su
1   National Museum of Marine Biology and Aquarium and Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
,
BR Peng
1   National Museum of Marine Biology and Aquarium and Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
,
SK Chou
2   Department of Biological Science and Technology, I-Shou University, Kaohsiung 824, Taiwan
,
MC Shih
2   Department of Biological Science and Technology, I-Shou University, Kaohsiung 824, Taiwan
,
YT Huang
3   Department of Nutrition, I-Shou University, Kaohsiung 824, Taiwan
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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One new 10-demethylated steroid, nephtheasteroid A (1), one new 19-oxygenated steroid, nephtheasteroid B (2), and four known steroids (3-6) were isolated from the wild-type soft coral Nephthea erecta. Two new cembranoids, culobophylins D (7) and E (8), along with eight known compounds (9 -16) were isolated from the cultured soft coral Lobophytum crassum. The structures were elucidated by means of IR, MS, and NMR techniques, and comparison of the NMR data with those of known analogues. Compound 1 was found to have a novel skeleton with the C10 demethylation of the normal steroid. Evaluation of the cytotoxicities showed that compound 9, the most potent of compounds 1-16, exhibited cytotoxicity against the K562, Molt-4, U937, Sup-T1 and Ca9 – 22 cancer cell lines with IC50 values of 1.2, 0.4, 2.4, 0.5 and 1.1 µg/mL, respectively. Moreover, compound 10 also showed significant U937 and Sup-T1 inhibitory activity, with IC50 values of 1.87 and 1.13 µg/mL.

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Acknowledgements: the Ministry of Science and Technology, Taiwan.

Keywords: Steroids, soft coral, Nephthea erecta, Lobophytum crassum, cytotoxicity.