Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596327
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

New terpenoids from Croton dichogamus Pax.

AHS Aldhaher
1   Department of Chemistry, FEPS, University of Surrey, Surrey, GU2 7XH, UK
2   Department of Biology, College of Science, University of Basrah, Basrah, IRAQ
,
MK Langat
1   Department of Chemistry, FEPS, University of Surrey, Surrey, GU2 7XH, UK
,
SL Schwikkard
3   Department of Chemistry, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston, KT1 2EE, UK
,
M Carew
3   Department of Chemistry, School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston, KT1 2EE, UK
,
DA Mulholland
1   Department of Chemistry, FEPS, University of Surrey, Surrey, GU2 7XH, UK
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

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The Croton genus, which belongs to the Euphorbiaceae family, is widely distributed in the subtropical and tropical regions, with more than 1300 species. Croton species are used in ethnomedicine to treat diabetes, cancer, digestive problems, constipation, dysentery, fever, hypercholesterolemia, hypertension, inflammation, intestinal worms, ulcers, malaria, pain, and weight-loss. The reported pharmacological activities include cytotoxic, anti-inflammatory, anti-leukemic, anti-mycobacterial, anti-malarial, anti-viral, antibacterial, and anti-oxidant activities [1 – 4]. Commercially, the active ingredient of an anti-ulcer agent KelnacTM is plaunotol which is present in the leaves of the Thai Croton sublyratus Kurz (C. stellapilosus) [1, 5]. C. dichogamus from Kenya was chosen for this study. Two new ent-halimane diterpenoids (1 – 2), two novel sesquiterpenes (3 – 4), two new crotofolanes (5 – 6) with the known ent-clerodane diterpenoids (7-10) and sesquiterpenes (11 – 13) were isolated from the roots of C. dichogamus. The structures of the compounds were determined using 1D and 2D NMR, IR and MS techniques. The compounds were tested for their anticancer activity against the CACO-2 cell line. Compound (13) showed modest anticancer activity at 30µM.

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Acknowledgements: Miss Areej Aldhaher would like to thanks the Higher Committee for Education Development in Iraq (HCED) for postgraduate funding.

Keywords: Croton dichogamus, diterpenoids, sesquiterpenes.

References:

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