Abstract
Objective We aimed to determine if fibroids in pregnancy, categorized by size, are associated
with adverse obstetrical outcomes.
Study Design Demographic, clinical, and delivery data were collected from charts of women with
singleton gestations who delivered at >20 weeks gestation with fibroids identified
at routine anatomy scan and their randomly selected age-matched controls. Largest
fibroid diameter was used to categorize small fibroids (≤5 cm) and large fibroids
(>5 cm).
Results We included 450 patients: 264 patients with fibroids (174 small, 90 large fibroids)
and 186 age-matched controls. Women with large fibroids had significantly greater
blood loss than women with small fibroids and women with no fibroids (p-value <0.0001 and <0.0001 after adjusting for delivery mode). When fibroid size was
compared individually, there was a significantly higher rate of primary cesarean section
in both small and large fibroid groups when compared with women with no fibroids (p-values 0.044 and 0.003 after adjusting for body mass index).
Conclusion Women with fibroids in pregnancy have higher rates of primary cesarean delivery and
are at significant risk for increased blood loss at the time of delivery.
Keywords
fibroid - leiomyoma - outcomes - pregnancy - blood loss - cesarean
