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Synthesis 2018; 50(08): 1667-1674
DOI: 10.1055/s-0036-1591758
DOI: 10.1055/s-0036-1591758
paper
Construction of Functionalized (Dihydro)thieno[2,3-c]chromene Derivatives via a Domino Michael Addition/Intramolecular Cyclization Reaction
We are grateful for the financial support by the Program for the National Natural Science Foundation of China (21272214).Further Information
Publication History
Received: 05 December 2017
Accepted after revision: 03 January 2018
Publication Date:
29 January 2018 (online)
Abstract
A one-pot synthesis of substituted (dihydro)thieno[2,3-c]chromene derivatives was developed through a Lewis base catalyzed domino Michael addition/intramolecular cyclization reaction between 3-nitro-2H-chromenes and thioamides. The desired (dihydro)thieno[2,3-c]chromene derivatives were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity in moderate to excellent yields.
Key words
3-nitro-2H-chromenes - thioamides - domino reactions - thieno[2,3-c]chromenes - heterocyclesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591758.
- Supporting Information
- CIF File
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