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Synlett 2017; 28(14): 1715-1718
DOI: 10.1055/s-0036-1591209
DOI: 10.1055/s-0036-1591209
cluster
Concise Synthesis of Lamellarin Alkaloids by C–H/N–H Activation: Evaluation of Metal Catalysts in Oxidative Alkyne Annulation
Generous support by the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC Grant agreement no. 307535, and the China Scholarship Council (fellowships to R.M. and S.-K.Z.) is gratefully acknowledged.Further Information
Publication History
Received: 02 July 2017
Accepted: 03 August 2017
Publication Date:
16 August 2017 (online)
§ These authors contributed equally
Published as part of the ISHC Conference Special Section
Abstract
The performance of various transition-metal catalysts was explored in the step-economical synthesis of naturally occurring lamellarin alkaloids by C–H/N–H activation. The oxidative alkyne annulation proceeded efficiently by using sustainable ruthenium(II) catalysis, which set the stage for a concise synthesis of lamellarin D, lamellarin H and derivatives thereof.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591209.
- Supporting Information
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For lamellarin syntheses, see:
For selected reviews, see: