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Synthesis 2017; 49(24): 5263-5284
DOI: 10.1055/s-0036-1590935
DOI: 10.1055/s-0036-1590935
review
Recent Progress on Radical Decarboxylative Alkylation for Csp3–C Bond Formation
We thank NSFC (grant no. 21402200, 21502191, 21672213), Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000), The 100 Talents Program, ‘The 1000 Youth Talents Program’ for financial support.Further Information
Publication History
Received: 27 July 2017
Accepted after revision: 25 August 2017
Publication Date:
08 November 2017 (online)
Abstract
Radical decarboxylation has emerged as an attractive method for the formation of C–C bonds starting from easily accessible carboxylic acids. In this review, we attempt to bring the readers up to date in this rapidly expanding field. Specifically, we will cover recent advances in Csp3–C bond formation via the radical decarboxylation of aliphatic carboxylic acids and their activated forms, such as N-hydroxyphthalimide esters (NHP esters), alkyl diacyl peroxides, alkyl peresters, and aryliodine(III) dicarboxylates. The scope and limitation of these transformations will be discussed, highlighting gaps in knowledge and research and examining the mechanisms underlying radical decarboxylation. We aim to make this review a stepping stone for further development in this field.
1 Introduction
2 Aliphatic Carboxylic Acids
3 N-Hydroxyphthalimide Esters (NHP Esters)
4 Alkyl Diacyl Peroxides
5 Alkyl Peresters
6 Aryliodine(III) Dicarboxylates
7 Conclusion
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