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Synthesis 2017; 49(22): 4996-5002
DOI: 10.1055/s-0036-1590821
DOI: 10.1055/s-0036-1590821
paper
Triflic Anhydride Promoted Intramolecular Cyclization of N-Aryl Cinnamides: Access to Polysubstituted Quinolin-2(1H)-ones
Financial support of this research by the National Natural Science Foundation of China (21502185, 21172211 and 21542006) is gratefully acknowledged.Weitere Informationen
Publikationsverlauf
Received: 24. April 2017
Accepted after revision: 05. Juni 2017
Publikationsdatum:
02. August 2017 (online)
Abstract
A facile and efficient synthesis of polysubstituted quinolin-2(1H)-ones is developed via intramolecular cyclization of readily available N-aryl cinnamides promoted by triflic anhydride in N,N-dimethyl trifluoroacetamide (DTA) under mild conditions.
Key words
C–C bond formation - cyclization reaction - heterocycles - quinolin-2(1H)-ones - triflic anhydrideSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590821.
- Supporting Information
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For our recent work, see:
For reviews on iminium triflate, see:
For selected examples on iminium triflate, see: