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Synlett 2017; 28(04): 461-466
DOI: 10.1055/s-0036-1589717
DOI: 10.1055/s-0036-1589717
letter
Iodine/Hydrogen Peroxide Promoted Intramolecular Oxidative C–O Bond Formation in Ethanol at Room Temperature: A Green Approach to 1,3-Oxazines
Autor*innen
Weitere Informationen
Publikationsverlauf
Received: 16. September 2016
Accepted after revision: 02. November 2016
Publikationsdatum:
18. November 2016 (online)
Abstract
An I2/H2O2-promoted intramolecular C–O bond-formation reaction of a variety of 1-(aminoalkyl)-2-naphthols or 2-(aminoalkyl)phenols to give the corresponding 1,3-oxazines was developed. The reaction is simple, atom-economic, and proceeds smoothly at room temperature under metal-free conditions in ethanol as solvent.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1589717.
- Supporting Information (PDF) (opens in new window)
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