Synlett 2017; 28(14): 1811-1815
DOI: 10.1055/s-0036-1588834
letter
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidines from β-Bromo-α,β-unsaturated Aldehydes and 2-Aminobenzimidazoles

Son Long Ho
Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea   Email: cscho@knu.ac.kr
,
Pham Duy Quang Dao
Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea   Email: cscho@knu.ac.kr
,
Chan Sik Cho*
Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Republic of Korea   Email: cscho@knu.ac.kr
› Author Affiliations
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0007563). P.D.Q. Dao thanks Y.M. Park Internal Medicine of Geoje Medical Center (Gyeongnam, Republic of Korea) for partial financial support during a stay in the Republic of Korea.
Further Information

Publication History

Received: 06 March 2017

Accepted after revision: 24 April 2017

Publication Date:
12 May 2017 (online)


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Abstract

β-Bromo-α,β-unsaturated aldehydes react with 2-aminobenzimidazoles by microwave irradiation in the presence of a base and magnesium sulfate to give the corresponding benzo[4,5]imidazo[1,2-a]pyrimidines in moderate to good yields.