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Synlett 2016; 27(20): 2795-2798
DOI: 10.1055/s-0036-1588595
DOI: 10.1055/s-0036-1588595
letter
Zinc Chloride Catalyzed, Dipolar Aprotic Solvent-Mediated, One-Pot Synthesis of 2-[(Benzo[d]thiazol-2-ylamino)(phenyl)methyl]phenols
Weitere Informationen
Publikationsverlauf
Received: 05. Juli 2016
Accepted after revision: 27. August 2016
Publikationsdatum:
08. September 2016 (online)
![](https://www.thieme-connect.de/media/synlett/201620/lookinside/thumbnails/st-2016-d0434-l_10-1055_s-0036-1588595-1.jpg)
◊ Both the authors contributed equally.
Abstract
A three-component one-pot method has been developed for the synthesis of 2-[(benzo[d]thiazol-2-ylamino)(phenyl)methyl]phenols from a variety of aldehydes, 2-amino-1,3-benzothiazoles, and phenols. Phenol, substituted phenols, and polyhydroxybenzenes participated well, providing the corresponding derivatives in good yields. In the case of polyhydroxybenzenes, for which the formation of positional isomers or dimers might have been possible, the sterically less hindered positional isomer was formed exclusively via the ortho-quinone methide.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588595.
- Supporting Information
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References and Notes
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For a review on Betti bases, see: