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Synlett 2017; 28(14): 1840-1844
DOI: 10.1055/s-0036-1588420
DOI: 10.1055/s-0036-1588420
letter
A Convenient Strategy for Remote C–H Bond Halogenation of 8-Aminoquinolines in the C5 Position
We are grateful to China Postdoctoral Science Foundation (2016M590967), Shaanxi Provincial Science and Technology Development Funds (2016JQ2022, 2016JQ2015), Shaanxi Provincial Postdoctoral Foundation (2016BSHEDZZ21), the National Fund for Fostering Talents of Basic Science (NFFTBS-J1103311, J1210057), and the National Natural Science Foundation of China (21402071) for financial support.Weitere Informationen
Publikationsverlauf
Received: 10. März 2017
Accepted after revision: 18. April 2017
Publikationsdatum:
10. Mai 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201714/lookinside/thumbnails/st-2017-w0174-l_10-1055_s-0036-1588420-1.jpg)
◊ These two authors contributed equally to this work.
Abstract
A highly efficient and convenient strategy has been developed for remote C–H bond halogenation of 8-aminoquinolines in good to excellent yields under transition-metal-free conditions. The reaction tolerates a variety of functional groups and can potentially be scaled up.
Key words
transition-metal-free - halogenation - C–H bond functionalization - aminoquinolines - regioselectivity - potassium persulfateSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588420.
- Supporting Information
Primary Data
- Primary Data
Primary data for this article are available online at http://www.thieme-connect.com/ejournals/toc/synthesis and can be cited using the following DOI: 10.4125/pd0094th.
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For selected examples of C–H functionalizations at the C2-position of quinolines, see:
For selected examples of C–H functionalizations at the C4-position of quinolines, see:
For selected examples of C–H functionalizations at the C8-position of quinolines, see: