3-Acyltetramic Acids: A Decades-Long Approach to a Fascinating Natural Product Family

Abstract

This account relates our quest for effective syntheses of 3-acyltetramic acids and also presents examples of our group’s increasing audacity to tackle the more intricate structural varieties of this compound class.

1 Introduction

2 A New Wittig-Based Access to Tetramic Acids

3 3-Acyltetramic Acids with Linear Side Chains

4 3-Decalinoyltetramic Acids

5 O- and N-Glycosylated 3-Acyltetramic Acids

6 Macrocyclic 3-Acyltetramic Acids

7 Miscellaneous Reactions

8 Whither to go from Here?

Key words

tetramic acids - natural products - metal chelates - bioactive compounds - Wittig reaction

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