Highly Regioselective Iodination of N-Phenylureas with Iodine/Trichloroisocyanuric Acid

Dedicated to the memory of Prof. José Barluenga

Abstract

An efficient regioselective iodination of N-phenylureas was developed using iodine/trichloroisocyanuric acid in acetonitrile at room temperature. This protocol proved to be effective on a broad range of substituted N-phenylureas, forming the p-iodinated compounds in 65–96% yield under mild and neutral conditions.

Key words

iodination - N-phenylureas - trichloroisocyanuric acid - iodine - S_EAr

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