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Synlett 2017; 28(07): 762-772
DOI: 10.1055/s-0036-1588146
DOI: 10.1055/s-0036-1588146
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Crossing the Ring: A Journey of the Nitroso-ene Reaction
Weitere Informationen
Publikationsverlauf
Received: 05. Dezember 2016
Accepted after revision: 16. Januar 2017
Publikationsdatum:
09. Februar 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201707/lookinside/thumbnails/st-2016-a0821-a_10-1055_s-0036-1588146-1.jpg)
Abstract
Recent progress in the nitroso-ene reaction indicates the potentially rich reactivity of the nitroso species. In this study, we highlight the synthetic efforts towards the construction of the aza-spirocyclic or aza-bridged ring embedded in biologically significant alkaloids via the proposed approach. Our endeavors along this direction are exemplified in the formal synthesis of (±)-cephalotaxine and the total synthesis of (–)-hosieine A.
1 Introduction
2 Aza-Spirocyclane: A Formal Synthesis of (±)-Cephalotaxine
3 Method Development
4 Aza-Bridge Ring: A Total Synthesis of (–)-Hosieine A
5 Epilogue
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For reviews see:
Reviews on nitroso-ene reactions see:
For early studies on the nitroso-ene reaction, see:
For a recent account, see:
See our early efforts on the construction of azepine using the iminium ion approach:
Reviews:
Review:
For recent examples, see: