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Synlett 2017; 28(07): 868-872
DOI: 10.1055/s-0036-1588134
DOI: 10.1055/s-0036-1588134
letter
Transition-Metal-Free N9-Amidoalkylation of Purines with N,N-Dialkylamides
Weitere Informationen
Publikationsverlauf
Received: 10. November 2016
Accepted after revision: 13. Dezember 2016
Publikationsdatum:
12. Januar 2017 (online)
![](https://www.thieme-connect.de/media/synlett/201707/lookinside/thumbnails/st-2016-w0757-l_10-1055_s-0036-1588134-1.jpg)
Abstract
A novel method for the selective N9-amidoalkylation of purines using N,N-dialkylamides as alkylation reagents via activation of sp3 C–H bond adjacent to an amide nitrogen atom has been developed in the presence of KI and tert-butyl hydroperoxide (TBHP). This method was simple to operate and provided series of purine derivatives in moderate to excellent yield.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588134.
- Supporting Information
-
References and Notes
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