Synthesis 2017; 49(06): 1349-1355
DOI: 10.1055/s-0036-1588092
paper
© Georg Thieme Verlag Stuttgart · New York

Efficient Ruthenium(II)-Catalyzed Direct Reductive Amination of Aldehydes under Mild Conditions Using Hydrosilane as the Reductant­

Bin Li*
School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China   Email: binli@wyu.edu.cn   Email: leeyib268@126.com
,
Jianxiong Zheng
School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China   Email: binli@wyu.edu.cn   Email: leeyib268@126.com
,
Weifeng Zeng
School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China   Email: binli@wyu.edu.cn   Email: leeyib268@126.com
,
Yibiao Li*
School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China   Email: binli@wyu.edu.cn   Email: leeyib268@126.com
,
Lu Chen
School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China   Email: binli@wyu.edu.cn   Email: leeyib268@126.com
› Author Affiliations
Further Information

Publication History

Received: 12 October 2016

Accepted after revision: 14 October 2016

Publication Date:
13 December 2016 (online)


Abstract

A direct reductive amination of aldehydes with anilines is performed with a ruthenium(II)-(arene) catalyst. The [RuCl2(p-cymene)]2/Ph2SiH2 catalytic system is very efficient for the synthesis of secondary amines and tertiary amines in good yields, and is highly chemoselective, tolerating a wide range of functional groups, such as NO2, CN, CO2Me, F, Cl, Br, OMe, Me, furyl and alkyl. We also report an interesting direductive amination of 2-ethylbutanal.

Supporting Information

 
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