RSS-Feed abonnieren
DOI: 10.1055/s-0036-1586728
Effects of Antiepileptic Drugs on Oxidative Stress Enzymes in Children with Epilepsy: Correlation with Child Psychopathology
Publikationsverlauf
12. Februar 2016
25. Juni 2016
Publikationsdatum:
08. August 2016 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029030/201602/lookinside/thumbnails/10-1055-s-0036-1586728_1600011-1.jpg)
Abstract
Antiepileptic drugs (AEDs) used in children may affect the oxidative status and child psychopathology. Our study conducted to investigate the possible causal–effect relationship between commonly used AEDs, oxidative stress enzymes, and child psychopathology. Overall, 84 children with epilepsy, and 42 controls were assessed by child behavioral checklist and blood level of oxidative stress enzymes before and after 6 months use of AEDs. We reported significant statistical difference between patients before and after therapy regarding attention problems (p-value < 0.001) and motor excess hyperactivity (p-value < 0.01). On the other hand, there were no significant statistical differences regarding the level of all oxidative stress enzymes after treatment. In conclusion, AEDs alter child psychopathology by another mechanism rather than changing oxidative stress enzymes.
-
References
- 1 Sobaniec W, Solowiej E, Kulak W, Bockowski L, Smigielska-Kuzia J, Artemowicz B. Evaluation of the influence of antiepileptic therapy on antioxidant enzyme activity and lipid peroxidation in erythrocytes of children with epilepsy. J Child Neurol 2006; 21 (7) 558-562
- 2 Cengiz M, Yüksel A, Seven M. The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children. Pharmacol Res 2000; 41 (4) 423-425
- 3 Sołowiej E, Sobaniec W. The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsy [in Polish]. Neurol Neurochir Pol 2003; 37 (5) 991-1003
- 4 Bolayir E, Celik K, Tas A, Topaktas S, Bakir S. The effects of oxcarbazepine on oxidative stress in epileptic patients. Methods Find Exp Clin Pharmacol 2004; 26 (5) 345-348
- 5 Erakovic V, Zupan G, Varljen J, Laginja J, Simonic A. Altered activities of rat brain metabolic enzymes in electroconvulsive shock-induced seizures. Epilepsia 2001; 42 (2) 181-189
- 6 Rauca C, Zerbe R, Jantze H. Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling. Brain Res 1999; 847 (2) 347-351
- 7 Bruce AJ, Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic Biol Med 1995; 18 (6) 993-1002
- 8 Rodenburg R, Stams GJ, Meijer AM, Aldenkamp AP, Deković M. Psychopathology in children with epilepsy: a meta-analysis. J Pediatr Psychol 2005; 30 (6) 453-468
- 9 Reilly C, Kent E, Neville BGR. Psychopathology in childhood epilepsy: a review. Child Adolesc Ment Health 2013; 18 (2) 65-75
- 10 Achenbach TM, Dumenci L. Advances in empirically based assessment: revised cross-informant syndromes and new DSM-oriented scales for the CBCL, YSR, and TRF: comment on Lengua, Sadowksi, Friedrich, and Fischer (2001). J Consult Clin Psychol 2001; 69 (4) 699-702
- 11 Achenbach TM, Dumenci L, Rescorla LA. DSM-oriented and empirically based approaches to constructing scales from the same item pools. J Clin Child Adolesc Psychol 2003; 32 (3) 328-340
- 12 Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70 (1) 158-169
- 13 Minami M, Yoshikawa H. A simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta 1979; 92 (3) 337-342
- 14 Johansson LH, Borg LA. A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 1988; 174 (1) 331-336
- 15 Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982; 126 (1) 131-138
- 16 Yagi K. Assay for serum lipid peroxide level and its clinical significance. In: Yagi KJ, ed. Lipid Peroxide in Biology and Medicine. New York, NY: Academic Press; 1982: 223-242
- 17 Hermann B, Whitman S. Psychopathology in epilepsy. The role of psychology in altering paradigms of research, treatment, and prevention. Am Psychol 1992; 47 (9) 1134-1138
- 18 Hermann BP, Whitman S. Behavioral and personality correlates of epilepsy: a review, methodological critique, and conceptual model. Psychol Bull 1984; 95 (3) 451-497
- 19 Austin JK, Harezlak J, Dunn DW, Huster GA, Rose DF, Ambrosius WT. Behavior problems in children before first recognized seizures. Pediatrics 2001; 107 (1) 115-122
- 20 DuPaul GJ, McGoey KE, Mautone JA. Pediatric pharmacology and psychopharmacology. In: Roberts MC, ed. Handbook of Pediatric Psychology. New York, NY: Guilford Press; 2003: 234-250
- 21 Austin JK, Dunn DW, Johnson CS, Perkins SM. Behavioral issues involving children and adolescents with epilepsy and the impact of their families: recent research data. Epilepsy Behav 2004; 5 (Suppl. 03) S33-S41
- 22 Pianta RC, Lothman DJ. Predicting behavior problems in children with epilepsy: child factors, disease factors, family stress, and child-mother interaction. Child Dev 1994; 65 (5) 1415-1428
- 23 Stores G, Williams PL, Styles E, Zaiwalla Z. Psychological effects of sodium valproate and carbamazepine in epilepsy. Arch Dis Child 1992; 67 (11) 1330-1337
- 24 Williams J, Bates S, Griebel ML , et al. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes?. Epilepsia 1998; 39 (10) 1064-1069
- 25 Dunn DW, Austin JK, Huster GA. Behaviour problems in children with new-onset epilepsy. Seizure 1997; 6 (4) 283-287
- 26 Grosso S, Longini M, Rodriguez A , et al. Oxidative stress in children affected by epileptic encephalopathies. J Neurol Sci 2011; 300 (1–2) 103-106
- 27 Arhan E, Serdaroglu A, Ozturk B , et al. Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy. Seizure 2011; 20 (2) 138-142
- 28 Yiş U, Seçkin E, Kurul SH, Kuralay F, Dirik E. Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. Epilepsy Res 2009; 84 (2–3) 232-237
- 29 Yüksel A, Cengiz M, Seven M, Ulutin T. Changes in the antioxidant system in epileptic children receiving antiepileptic drugs: two-year prospective studies. J Child Neurol 2001; 16 (8) 603-606
- 30 Michoulas A, Tong V, Teng XW, Chang TKH, Abbott FS, Farrell K. Oxidative stress in children receiving valproic acid. J Pediatr 2006; 149 (5) 692-696
- 31 Verrotti A, Scardapane A, Franzoni E, Manco R, Chiarelli F. Increased oxidative stress in epileptic children treated with valproic acid. Epilepsy Res 2008; 78 (2–3) 171-177
- 32 Trimble MR. New antiepileptic drugs and psychopathology. Neuropsychobiology 1998; 38 (3) 149-151
- 33 Aldenkamp AP, Alpherts WCJ, Sandstedt P , et al. Antiepileptic drug-related cognitive complaints in seizure-free children with epilepsy before and after drug discontinuation. Epilepsia 1998; 39 (10) 1070-1074
- 34 Mandelbaum DE, Burack GD. The effect of seizure type and medication on cognitive and behavioral functioning in children with idiopathic epilepsy. Dev Med Child Neurol 1997; 39 (11) 731-735