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Semin Neurol 2016; 36(03): 233-243
DOI: 10.1055/s-0036-1581993
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications

Gregoire Boulouis
1   Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts
,
Andreas Charidimou
1   Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts
,
Steven M. Greenberg
1   Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
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Publication History

Publication Date:
23 May 2016 (online)

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Abstract

Sporadic cerebral amyloid angiopathy is a small vessel disorder defined pathologically by progressive amyloid deposition in the walls of cortical and leptomeningeal vessels resulting from disruption of a complex balance between production, circulation, and clearance of amyloid-β peptide (Aβ) in the brain. Cerebral amyloid angiopathy is a major cause of lobar symptomatic intracerebral hemorrhage, transient focal neurologic episodes, and a key contributor to vascular cognitive impairment. The mechanisms and consequences of amyloid-β deposition at the pathological level and its neuroimaging manifestations, clinical consequences, and implications for patient care are addressed in this review.

Keywords

cerebral amyloid angiopathy - cerebral small vessel disease - intracerebral hemorrhage - dementia
 

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