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DOI: 10.1055/s-0036-1579773
Effect of Moxibustion on T lymphocyte subsets of Helicobacter pylori-associated Gastritis Rats
Objective: To explore the effect of moxibustion on gastric inflammatory injury and expression of CD3+, CD4+, CD8+, CD4+/CD8+ of rats with Helicobacter pylori (H. pylori)-associated gastritis, to reveal the mechanisms underlying the protective effect of moxibustion against gastric inflammatory injury.
Methods: 40 healthy SD rats were randomly divided into 4 groups: blank group (group A), Hp model group (group B), moxibustion groups (group C) and electro-acupuncture group (group D). Gastritis was induced by oral gavage with live H.pyloria. Contents of CD3+, CD4+, CD8+ and CD4+/CD8+ was detected by flow cytometry.
Results: Compared to group A, content of CD3+, CD4+ and CD4+/CD8+ decreased (P<0.01), content of CD8+ increased (P<0.01). Compared to group B, content of CD3+, CD4+ and CD4+/CD8+ (P<0.05) increased, content of CD8+ decreased (P<0.05). No significant difference in group D (P>0.05). Compared to group D, CD4+/CD8+ (P<0.05) increased.
Conclusion: The mechanisms of reducing H. pylori-induced gastric mucosal inflammatory injury after moxibustion therapy associated with enhancement of body immunity, resistance to microbial pathogens invasion. The effect on Immunity Enhancement of moxibustion is better than that of electro-acupuncture therapy.
Acknowledgements: Most support for this research from the National Natural Science Foundation of China (No. 81072867 and No. 81403486) is gratefully acknowledged.